INTRAMUSCULAR LIPIDS IN OBESITY & ENDURANCE PERFORMANCE

人局灶性癫痫的4.1T质子核磁共振波谱 （R01NS33919） 简介：高达20%的局灶性癫痫患者（约 400，000在美国）未能响应抗癫痫药物。 目前，这些难治性患者中只有不到三分之一的人 被认为是高效手术的候选人， 癫痫集中因为术前评估是昂贵的， 不准确，而且经常是侵入性的（因此是有风险的）。 方法：采用定量MRSI（Core Project I）和MRI（Core Project I）， 项目四）方法，测定1H的敏感性和特异性 MRSI和MR容量测定与EEG、PET、发作SPECT和常规进行比较 MRI 1.5T。 结果：早期研究表明，1H MRSI比1H MRSI更能反映人的免疫功能。 敏感性和特异性优于PET、发作期SPECT或常规1.5T MRI。 1.5T下的容量测定不那么灵敏，但仍有贡献 重要的独立信息。 讨论：无创性的高敏感性和特异性 MRSI和MRI定位致痫灶可 降低术前评估的成本和风险， 更难治的患者进行有效的手术治疗。 当 实施头部梯度线圈和快速成像（核心项目IV 和II），则4.1T下的容量测定将常规纳入 议定书

Proton NMR Spectroscopy of Human Focal Epilepsy at 4.1T (R01NS33919) Introduction: Up to 20% of focal epilepsy patients (about 400,000 in the USA) fail to respond to anti-epileptic medication. Fewer than one-third of these refractory patients are currently considered candidates for the highly effective surgery to resect the seizure focus because the presurgical evaluation is costly, inaccurate, and often invasive (thus risky). Methods: Using quantitative MRSI (Core Project I) and MRI (Core Project IV) methods, determine the sensitivity and specificity of 1H MRSI and MR volumetry compared to EEG, PET, ictal SPECT, and routine MRI at 1.5T. Results: Early studies indicate that 1H MRSI is much more sensitive and specific than PET, ictal SPECT, or routine 1.5T MRI. Volumetry at 1.5T is not as sensitive, but still contributes significant independent information. Discussion: The high sensitivity and specificity of noninvasive MRSI and MRI for localization of the epileptogenic seizure focus could reduce the cost and risk of presurgical evaluation and could qualify more refractory patients for effective surgical treatment. When the head gradient coil and rapid imaging are implemented (Core Projects IV and II), then volumetry at 4.1T will be routinely included in the protocol.