SUBSTANCE P AND DIABETES IMPAIRED WOUND HEALING

P 物质与糖尿病损伤的伤口愈合

• 批准号: 2892484
• 负责人: Ted W Reid
• 金额: $ 14.8万
• 依托单位: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2892484
• 关键词: disease /disorder model; fibroblast growth factor; immunocytochemistry; insulin; insulin dependent diabetes mellitus; insulinlike growth factor; laboratory rat; neurotrophic factors; pathologic process; streptozotocin; substance P; wound healing

The skin is densely innervated with sensory neuronal fibers that synthesize several neuropeptides, including the eleven residue tachykinin, substance P (SP). Among SP effects are inflammation mediation and subsequent wound healing. Major objectives of this study are to: (1) determine the optimum time and dose of streptozotocin for the development of a diabetic rat model by measurement of SP content and SP containing nerve density; (2) to evaluate SP depletion in cutaneous nerves in the streptozotocin diabetic rat model of type I diabetes, using immunohistochemical analysis; (3) to determine the stability of formulations of SP and SP analogs under different time and temperature conditions; and (4) to develop SP and SP analog treatments for wound healing in the streptozotocin rat model of type I diabetes. The long- term goal is ultimately to develop effective SP therapies for use in promoting wound healing in diabetic patients.

皮肤由感觉神经元纤维密集地支配， 合成几种神经肽，包括11个残基 速激肽，P物质（SP）。SP的影响包括炎症 调解和随后的伤口愈合。本研究的主要目的 目的：（1）确定链脲佐菌素的最佳给药时间和剂量， 糖尿病大鼠模型的建立， SP含量神经密度;（2）评估皮肤中SP耗竭 I型糖尿病的链脲佐菌素糖尿病大鼠模型中的神经， 采用免疫组化分析;（3）确定稳定性 SP和SP类似物在不同时间和温度下的配方 （4）开发SP和SP类似物治疗创伤的方法 在链脲佐菌素大鼠I型糖尿病模型中的愈合。很长的- 长期目标是最终开发有效的SP疗法，用于 促进糖尿病患者的伤口愈合。