EFFECT OF GROWTH FACTORS ON LENS CELLS IN CULTURE

培养中生长因子对晶状体细胞的影响

• 批准号: 3261083
• 负责人: Ted W Reid
• 金额: $ 12.59万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3261083
• 关键词: biological information processing; biological models; cataract; cell growth regulation; cell membrane; chromatography; cytogenetics; epidermal growth factor; genetic regulation; growth factor receptors; hormone regulation /control mechanism; insulin; laboratory mouse; laboratory rabbit; laboratory rat; lens; membrane permeability; mitogens; monoclonal antibody; radiotracer; retinoblastoma; tissue /cell culture

This grant represents an attempt to understand in a systematic way, the various hormones and growth factors which control the growth and metabolism of lens cells in culture. The specific aims of the research are: 1) To study external signals that modify lens cell proliferation; 2) To obtain information on the nature of surface receptors on lens cells; 3) To investigate the primary biological response elicited by growth factors; 4) To look at possible models for the transfer of information across the cell membrane; 5) The use of genetics to approach the mechanism of action of growth factors. It is felt that this molecular approach to growth regulation using defined external signals should yield important information on the problem of cataractogenesis.

这项资助代表了一种尝试以系统的方式理解 控制生长和新陈代谢的各种激素和生长因子 培养物中的晶状体细胞。 研究的具体目标是： 1） 研究改变晶状体细胞增殖的外部信号； 2) 获得 有关晶状体细胞表面受体性质的信息； 3) 至 研究生长因子引起的主要生物反应； 4） 研究跨细胞信息传输的可能模型 膜; 5）利用遗传学来研究作用机制 生长因子。 人们认为这种分子生长方法 使用定义的外部信号进行监管应该会产生重要的结果 有关白内障发生问题的信息。