EFFECT OF GROWTH FACTORS ON LENS CELLS IN CULTURE

培养中生长因子对晶状体细胞的影响

• 批准号: 3261079
• 负责人: Ted W Reid
• 金额: $ 11.73万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3261079
• 关键词: biological information processing; biological models; cataract; cell growth regulation; cell membrane; chromatography; cytogenetics; epidermal growth factor; genetic regulation; hormone regulation /control mechanism; insulin; lens; membrane permeability; monoclonal antibody; radiotracer; retinoblastoma; tissue /cell culture

This grant represents an attempt to understand in a systematic way, the various hormones and growth factors which control the growth and metabolism of lens cells in culture. The specific aims of the research are: 1) To study external signals that modify lens cell proliferation; 2) To obtain information on the nature of surface receptors on lens cells; 3) To investigate the primary biological response elicited by growth factors; 4) To look at possible models for the transfer of information across the cell membrane; 5) The use of genetics to approach the mechanism of action of growth factors. It is felt that this molecular approach to growth regulation using defined external signals should yield important information on the problem of cataractogenesis.

这项赠款代表了一种尝试，以系统的方式了解， 控制生长和代谢的各种激素和生长因子 培养的透镜细胞。 本研究的具体目的是：（1） 研究改变透镜细胞增殖的外部信号; 2）获得 关于透镜细胞表面受体性质的信息; 3） 研究生长因子引起的主要生物学反应; 4） 为了研究细胞内信息传递的可能模型 5）使用遗传学方法来探讨膜的作用机制， 生长因子 人们认为这种分子生长方法 使用明确的外部信号进行监管， 关于白内障形成问题的信息。