BRAIN INFORMATION MANAGEMENT SYSTEM

将有关大脑的新信息与 现有的知识正在呈指数级增长。本项目致力于 创建大脑信息管理系统(BIMS)的问题 为了让科学家容易地获得这两种信息， 万维网上的临床医生和学生。因为大多数知识 是基于对非人类灵长类动物的研究， 信息被索引到计算机化的猕猴模板地图集 大脑是我们去年在网上建立的。在1998年，我们大大地 通过添加大脑词汇表NeuroNames来增强网站 我们实验室开发的结构并整合到 国家医学图书馆统一医学语言系统。 NeuroName将神经科学的标准化提升到一个新的水平 通过定义7000多个经典神经解剖学名称进行研究 就一套标准的初级大脑结构而言。这些是 在非人灵长类动物中通过链接到模板地图集和 在人类通过链接到另一个网站，数字解剖学家的 部门华盛顿大学生物结构学教授。 BIMS的未来扩展是通过应用 用于管理图像的地理信息系统(GIS)软件 关于大脑的信息。约1500幅插图，来自 文献被映射到地图集中的模板以在 多种神经科学数据位置的标准格式， 例如，特定种类的神经细胞、特定基因的区域 表达，以及电刺激、化学处理 或损伤会影响行为的特定方面。此外, 绘制地图的原始数据是在对 1型腺酰环化酶在大鼠海马区的分布 猕猴。资助国家卫生研究院拨款00166卢比和LM/OD 06243卢比。D.M.鲍登， 罗伯逊，J.E.，杜巴赫，J.，Martin，R.F.(1998)神经名称/模板 地图集/脑信息；神经科学科，区域灵长类研究 华盛顿大学中心。(网站 Http://rprcsgi.rprc.washington.edu/neuronames/；内容相当于 500页正文)Robertson，J.E.，Martin，R.F.Dubach，J.G.和Bowden， D.M.NeuroNames和模板图谱。WebNet‘98世界大会 互联网和内联网，佛罗里达州奥兰多。1998年11月7日至12日。 (摘要)鲍登，D.M.，马丁，R.F.，罗伯逊，J.E.和J.G. 杜巴赫。NeuroName和猕猴大脑的模板图谱。SoC。 《神经科学》，1998，安。开会。加利福尼亚州洛杉矶11月7日至12日， 1998年。(摘要)

The problem of integrating new information about the brain with existing knowledge is expanding exponentially. This project addresses the problem by creating a Brain Information Management System (BIMS) to make both kinds of information readily available to scientists, clinicians and students on the World Wide Web. Since most knowledge about the human brain is based on studies of nonhuman primates, the information is indexed to a computerized Template Atlas of the macaque brain which we established on the Web last year. In 1998 we greatly enhanced the website by adding NeuroNames, a glossary of brain structures developed in our laboratory and incorporated into the Unified Medical Language System of the National Library of Medicine. NeuroNames brings a new level of standardization to neuroscientific research by defining more than 7,000 classical neuroanatomical names in terms of a standard set of primary brain structures. These are illustrated in the nonhuman primate by links to the Template Atlas and in the human by links to another website, the Digital Anatomist of the Dept. of Biological Structure at the University of Washington. Future expansion of the BIMS was furthered by application of Geographical Information Systems (GIS) software to managing image information about the brain. Some 1500 illustrations from the literature were mapped to templates in the Atlas to display in a standard format the location of many kinds of neuroscientific data, e.g., particular kinds of nerve cell, areas of specific gene expression, and sites where electrical stimulation, chemical treatment or lesions influence specific aspects of behavior. In addition, original data for mapping were generated in a microscopic study of the distribution of type-1 adenylyl cyclase in the hippocampus of the macaque. FUNDING NIH grants RR00166 and LM/OD 06243. Bowden, D.M., Robertson, J.E., Dubach, J., Martin, R.F. (1998) NeuroNames/Template Atlas/Brain Information; Neurosciences Div., Regional Primate Research Center, University of Washington. (Website http://rprcsgi.rprc.washington.edu/neuronames/; contents equivalent to 500 page text) Robertson, J.E., Martin, R.F. Dubach, J.G. and Bowden, D.M. NeuroNames and the Template Atlas. WebNet '98 World Conference of the WWW, Internet & Intranet, Orlando, FL. November 7-12, 1998. (Abstract) Bowden, D.M., Martin, R.F., Robertson, J.E., and J.G. Dubach. NeuroNames and a template atlas of the macaque brain. Soc. for Neuroscience, 1998 Ann. Meeting. Los Angeles, CA. Nov. 7-12, 1998. (Abstract)