Spatial Information Management Resources for Human Brain

描述（申请人提供）：神经科学家和临床医生需要强大的计算机数据和图像管理资源来处理有关大脑的新信息。这些资源必须是全面的、可获得的，并且能够在不需要人为干预的情况下直接与其他计算机化系统通信。经典的神经解剖学标志为整合新的和现有的关于大脑的信息提供了一个重要的参考框架。Braininfo是一个网络资源，其中的信息是由一个全面的神经解剖学命名索引。命名，神经名称，是完全集成的统一医学语言系统的国家医学图书馆。它包括人类和非人类灵长类动物大脑的术语。命名法的适当部分已纳入神经解剖学定义系统，该系统通过参考非人类灵长类动物大脑图谱来说明结构概念。我们建议创建一个三维人脑计算机图谱，并将这个定义系统扩展到人脑，建立机制，使Brainlnfo网站的访问者可以将数据映射到网络上的大脑图谱中，并建立Brainlnfo与两个最广泛的基于网络的人脑功能数据源之间的兼容性和互操作性。braininfo和NeuroNames的资源目标是加速获取和传播有关大脑的现有和新的科学知识。这将通过应用数字通信技术来实现，以一种适合神经科学家、临床医生和神经解剖学学生的知识结构和直觉搜索策略的方式，通过网络实现关于大脑的信息的即时交流。(http://braininfo.rprc.washington.edu)

DESCRIPTION (provided by applicant): Neuroscientists and clinicians need powerful computerized data and image management resources to deal with the rising tide of new information about the brain. Such resources need to be comprehensive, accessible and capable of communicating directly with other computerized systems without the need for human intervention. Classical neuroanatomical landmarks provide an essential frame of reference for integrating new and existing information about the brain. Braininfo is a Web resource in which information is indexed by a comprehensive neuroanatomical nomenclature. The nomenclature, NeuroNames, is fully integrated with the Unified Medical Language System of the National Library of Medicine. It includes terminology for both the human and the nonhuman primate brain. Appropriate parts of the nomenclature have been incorporated into a system of neuroanatomical definitions that illustrates structural concepts by reference to an atlas of the nonhuman primate brain. We propose to create a 3-dimensional computerized atlas of the human brain and to extend this definitional system to the human brain, to establish mechanisms whereby visitors to the Brainlnfo website can map data into brain atlases on the Web, and to establish compatibility and interoperability between Brainlnfo and two of the most extensive web-based sources of data on human brain function. The resource objective of Brainlnfo and NeuroNames is to accelerate the acquisition and distribution of existing and new scientific knowledge about the brain. This will be accomplished by applying digital communications technology to enable immediate communication of information about the brain via the Web in a manner tailored to the knowledge structure and intuitive search strategies of neuroscientists, clinicians, and students of neuroanatomy. (http://braininfo.rprc.washington.edu)