TYPE 1 ADENYLYL CYCLASE IN PRIMATE BRAIN

1型腺酰环化酶(AC-1)是一种位于大脑中的酶 它被认为在学习和学习中发挥着重要作用 记忆。一项在大鼠身上的研究表明，AC-1的基因表达 在海马区的几组神经元中， 明显与阿尔茨海默氏症有关的大脑的亚结构 与痴呆症相关的疾病和其他神经障碍。在……里面 在这项研究中，我们检验了AC-1位于 海马体，特别是在灵长类动物的神经通路中 海马区，损伤与长时程增强的损伤有关 增强，一种神经生理现象，据信 在神经细胞水平上调节学习。研究表明， 事实上，AC-1很容易在海马区得到证实 灵长类的形成。此外，最突出的是在 苔藓纤维通路是海马区结构中最重要的一个亚结构 显然与长期强化有关。资助美国国立卫生研究院拨款 LM/OD 06243和RR00166。

Type-1 adenylyl cyclase (AC-1) is an enzyme located in the brain that has been implicated as playing an important role in learning and memory. A study in the rat showed that the gene for AC-1 is expressed in several groups of neurons in the hippocampal formation, a substructure of the brain that is clearly involved in Alzheimer's disease and other neurological disorders associated with dementia. In this study we tested the hypothesis that AC-1 is located in the hippocampus of primates, and particularly in nerve pathways of the hippocampus, where damage is associated with impairment of long-term potentiation, a neurophysiological phenomenon that is believed to mediate learning at the level of the nerve cell. The study showed that, indeed, AC-1 was readily demonstrated in the hippocampal formation of the primate. Furthermore it was most prominent in the mossy fiber pathway, a substructure of the hippocampal formation most clearly implicated in long-term potentiation. FUNDING NIH grants LM/OD 06243 and RR00166.