ADARC CENTER FOR AIDS RESEARCH: VACCINE & THERAPY

ADARC 艾滋病研究中心：疫苗

• 批准号: 6116179
• 负责人: DAVID D HO
• 金额: $ 5.31万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116179
• 关键词: AIDS; Mammalia; animal tissue; communicable diseases; immunology; inflammation; lymphatic system; vaccines; virus

Dr. Torsten Wiesel, President of The Rockefeller University (RU), and Dr. Herbert Pardes, Dean of the Medical Faculty of Columbia University (CU), jointly propose the establishment of the Columbia-Rockefeller Center for AIDS Research (CR-CFAR), an administrative structure bridging AIDS investigators from our two Universities located in the City of New York. The CR-CFAR will be governed by a series of by-laws overseen by Drs. David Ho (Director, Aaron Diamond AIDS Research Center, RU) and Jeremy Luban (Chief, Division of Molecular Virology, CU), and by an Executive Steering Committee consisting of Drs. Yuan Chang, Leonard Chess, Anke Ehrhardt, Stephen Goff, Wayne Hendrickson, Martin Markowitz, Preston Marx, John Moore and Ralph Steinman. The CR-CFAR members will be comprised of over 70 investigators drawn from the Aaron Diamond AIDS Research Center (RU), the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute (CU), the General Clinical Research Center (GCRC) at the RU Hospital, the Columbia University Pediatric and Adult ACTUs, seven clinical departments at the Columbia-Presbyterian Medical Center and at the Harlem Hospital Medical Center (CU), ten departments of basic science at CU and RU, as well as the Laboratory for Experimental Medicine and Surgery in Primates (RU). Two goals unify all CR-CFAR participants. The first goal is to understand more about the mechanisms of HIV replication, transmission and pathogenesis, with studies ranging from atomic resolution of viral protein structure to the psycho-social dynamics of the inner-city community. The second goal is to integrate this information into programs developing anti-viral therapeutics and vaccines, and community outreach and behavioral intervention strategies. By supporting seven modifiable core facilities (Administration, Development, Virology, Immunology, Clinical Resources, Structural Biology and Primate Biology), the CR-CFAR will promote three major objectives 1) to enhance the outstanding research programs that are already in place by providing, or simply rendering more accessible, shared research facilities; 2) to help recruit junior faculty to our programs and to our institutions, and to encourage established investigators from within the ranks of our faculty to develop research programs in AIDS-related topics; and 3) to promote dialogue leading to new productive collaborations involving CR-CFAR members. FUNDING PUBLICATIONS None

洛克菲勒大学校长Torsten Wielter博士， 以及哥伦比亚医学院院长赫伯特帕德斯博士 大学（CU），共同提议设立 哥伦比亚-洛克菲勒艾滋病研究中心（CR-CFAR） 一个行政结构，将艾滋病调查人员从我们的两个 位于纽约的大学。 CR-CFAR将 由大卫何博士（董事， Aaron Diamond艾滋病研究中心，RU）和Jeremy Luban（主任， 分子病毒学分部，CU），并由执行指导 委员会成员包括：Yuan Chang博士、伦纳德Chess博士、Anke Ehrhardt博士、 斯蒂芬·戈夫、韦恩·亨德里克森、马丁·马科维茨、普雷斯顿、马克思、约翰 摩尔和拉尔夫·斯坦曼。 CR-CFAR成员将包括 来自Aaron Diamond艾滋病研究中心的70多名研究人员 中心（RU），艾滋病毒临床和行为研究中心，在 纽约州立精神病研究所（CU），普通临床 哥伦比亚大学RU医院研究中心（GCRC） 儿科和成人ACTU，七个临床部门在 哥伦比亚长老会医疗中心和哈莱姆医院 医学中心（CU），CU和RU的十个基础科学部门， 实验医学和外科实验室 灵长类动物（RU）。 有两个目标将所有CR-CFAR参与者团结在一起。 第一 目标是了解更多关于艾滋病毒复制的机制， 传播和发病机制，研究范围从原子 病毒蛋白质结构的解析， 市中心社区 第二个目标是整合这个 将信息纳入开发抗病毒疗法的计划， 疫苗，社区外展和行为干预 战略布局 通过支持七个可修改的核心设施， （管理、开发、病毒学、免疫学、临床 资源，结构生物学和灵长类生物学），CR-CFAR将 推进三大目标1）加强优秀科研 通过提供或简单地呈现已经到位的程序， 更方便，共享的研究设施; 2）帮助招募初级 教师对我们的计划和我们的机构，并鼓励 从我们的教师队伍中建立了调查人员， 发展与爱滋病有关的研究计划;及3）推广 对话导致新的富有成效的合作，包括CR-CFAR 成员 资助出版物