DEVELOPMENT OF RHESUS MODEL FOR HCV INFECTION: HEPATITIS

HCV 感染：肝炎的恒河猴模型的开发

• 批准号: 6116206
• 负责人: GARY B BASKIN
• 金额: $ 16.14万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116206
• 关键词: Mammalia; bacteria; communicable diseases; liver; model design /development

Only humans and chimpanzees are known to be infected by hepatitis C virus (HCV). There is currently no small animal model of HCV infection or disease, although one is desparately needed. Chimpanzees have been infected by direct intrahepatic inoculation of an infectious molecular clone of HCV. We have inoculated 3 rhesus monkeys intrahepatically with the same clone, in an attempt to create a rhesus model of HCV infection. To date, there is no elevation of hepatic enzymes or clear evidence of circulating viral RNA in any of the inoculated monkeys. FUNDING Ely Lilly (Baskin, PI) $50,000 PUBLICATIONS None

目前已知只有人类和黑猩猩会感染肝炎 C病毒（HCV）。 目前尚无HCV小动物模型 感染或疾病，尽管迫切需要一种。 黑猩猩 因直接肝内接种传染性病原体而被感染 HCV的分子克隆。 我们已经给3只恒河猴接种了疫苗 肝内使用相同的克隆，试图创造恒河猴 HCV感染模型。 迄今为止，肝功能未见升高。 任何酶或循环病毒 RNA 的明确证据 已接种疫苗的猴子。 资助 Ely Lilly（巴斯金，PI）50,000 美元 出版物 无