DEVELOPMENT OF RHESUS MODEL FOR HCV INFECTION: HEPATITIS

目前已知只有人类和黑猩猩会感染肝炎 丙型肝炎病毒（HCV）。 目前尚无HCV的小动物模型 感染或疾病，虽然一个是迫切需要的。 黑猩猩 通过直接肝内接种传染性 HCV的分子克隆。 我们给三只恒河猴接种了疫苗 用同一克隆体进行肝内移植， HCV感染模型。 到目前为止，没有肝硬化 酶或明确的证据循环病毒RNA在任何 接种过疫苗的猴子 资助伊利莉莉（巴斯金，PI）50，000美元 出版物

Only humans and chimpanzees are known to be infected by hepatitis C virus (HCV). There is currently no small animal model of HCV infection or disease, although one is desparately needed. Chimpanzees have been infected by direct intrahepatic inoculation of an infectious molecular clone of HCV. We have inoculated 3 rhesus monkeys intrahepatically with the same clone, in an attempt to create a rhesus model of HCV infection. To date, there is no elevation of hepatic enzymes or clear evidence of circulating viral RNA in any of the inoculated monkeys. FUNDING Ely Lilly (Baskin, PI) $50,000 PUBLICATIONS None