A multicentre randomised controlled trial of probiotic and peanut oral immunotherapy for the treatment of peanut allergy

益生菌和花生口服免疫疗法治疗花生过敏的多中心随机对照试验

• 批准号: nhmrc : 1105429
• 负责人: Prof Katrina Allen
• 金额: $ 198.89万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/multicentre-randomised-controlled-peanut-allergy/662829
• 关键词: multicentre; randomised; controlled; trial; probiotic

A curative treatment for food allergy is required to prevent deaths and improve management. We recently trialed a new treatment for peanut allergy that was highly effective. Over 80% of children treated with Probiotic and Peanut Oral ImmunoTherapy (PPOIT) tolerated peanut as compared to 4% of children who received placebo. We now plan a larger multicentre trial to confirm these findings. If successful, we will have established a new treatment for peanut allergy and possibly all food allergies.

需要对食物过敏进行根治性治疗，以防止死亡和改善管理。我们最近试验了一种治疗花生过敏的新方法，非常有效。超过80%的接受益生菌和花生口服免疫疗法（PPOIT）治疗的儿童能够耐受花生，而接受安慰剂治疗的儿童只有4%。我们现在计划进行一项更大规模的多中心试验来证实这些发现。如果成功，我们将建立一种新的治疗花生过敏和可能所有的食物过敏。