REGULATION OF CEREBRAL BLOOD FLOW BY THE ROSTRAL VENTROLATERAL MEDULLA

头端腹外侧延髓对脑血流的调节

• 批准号: 6109475
• 负责人: EUGENE V GOLANOV
• 金额: $ 24.72万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6109475
• 关键词: blood flow measurement; brain electrical activity; brain mapping; brain metabolism; central neural pathway /tract; cerebral cortex; cerebral ischemia /hypoxia; electroencephalography; hemodynamics; immunocytochemistry; intercellular connection; laboratory rat; medulla oblongata; neuroregulation; vascular smooth muscle nervous control; vasodilation; vasomotion

The objective of this continuing project is to investigate the mechanisms and pathway through which neurons in the rostral ventrolateral medulla (RVL) regulate the cerebral circulation. Excitation of neurons of the RVL elevates regional cerebral blood flow (rCBF) within the cerebral cortex without elevating cerebral metabolism. These neurons also mediate half of the cerebrovascular vasodilation to hypoxia. Three studies will be undertaken which combine methods of microelectrical and chemical stimulation, neuronal inactivation, recording of bioelectrical activity and rCBF, and tract tracing and immunocytochemistry in anesthetized rats. Project I will test the hypotheses that (a) excitation of a distinctive group of neurons in the caudal RVL (RVLc) elevates rCBF in the cerebral cortex; (b) these RVLc neurons are reflexively excited from FN, NTS, and oxygen sensitive neurons of rostral RVL (RVLr); (c) the pathway to the cortex from RVLc is indirect and relays through a subcortical projection probably localized to Zl; (d) vasodilatory effects of excitation of RVLc of Zl neurons depend upon the integrity of cortical neurons for the final expression of elevated rCBF; (e) the vasodilator pathway represented in the RVLs is the common pathway through which activation of FN, NTS, and RVLr also produces a slowing of the EEG and elevation of rCBF. The study will provide evidence for the first time of a full pathway of the brainstem linking visceral afferent activity with the circulation and electrical brain activity.

这个持续项目的目标是调查