REGULATION OF CEREBRAL BLOOD FLOW BY THE ROSTRAL VENTROLATERAL MEDULLA
头端腹外侧延髓对脑血流的调节
基本信息
- 批准号:6462989
- 负责人:
- 金额:$ 11.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-01 至 2003-06-30
- 项目状态:已结题
- 来源:
- 关键词:blood flow measurement brain circulation brain electrical activity brain mapping brain metabolism central neural pathway /tract cerebral cortex cerebral ischemia /hypoxia electroencephalography hemodynamics immunocytochemistry intercellular connection laboratory rat medulla oblongata neuroregulation vascular smooth muscle nervous control vasodilation vasomotion
项目摘要
The objective of this continuing project is to investigate the
mechanisms and pathway through which neurons in the rostral
ventrolateral medulla (RVL) regulate the cerebral circulation.
Excitation of neurons of the RVL elevates regional cerebral blood
flow (rCBF) within the cerebral cortex without elevating cerebral
metabolism. These neurons also mediate half of the
cerebrovascular vasodilation to hypoxia. Three studies will be
undertaken which combine methods of microelectrical and chemical
stimulation, neuronal inactivation, recording of bioelectrical activity
and rCBF, and tract tracing and immunocytochemistry in
anesthetized rats. Project I will test the hypotheses that (a)
excitation of a distinctive group of neurons in the caudal RVL
(RVLc) elevates rCBF in the cerebral cortex; (b) these RVLc
neurons are reflexively excited from FN, NTS, and oxygen
sensitive neurons of rostral RVL (RVLr); (c) the pathway to the
cortex from RVLc is indirect and relays through a subcortical
projection probably localized to Zl; (d) vasodilatory effects of
excitation of RVLc of Zl neurons depend upon the integrity of
cortical neurons for the final expression of elevated rCBF; (e) the
vasodilator pathway represented in the RVLs is the common
pathway through which activation of FN, NTS, and RVLr also
produces a slowing of the EEG and elevation of rCBF. The study
will provide evidence for the first time of a full pathway of the
brainstem linking visceral afferent activity with the circulation and
electrical brain activity.
这一持续项目的目标是调查
头侧皮层神经元
延髓腹外侧区(RVL)调节脑循环。
RVL神经元的兴奋提高局部脑血流量
脑血流(rCBF)在大脑皮质内,不升高大脑
新陈代谢. 这些神经元也介导了
脑血管舒张至缺氧。 三项研究将
采用微电子和化学方法的联合收割机
刺激,神经元失活,生物电活动记录
和rCBF,以及束追踪和免疫细胞化学,
麻醉大鼠。 项目一将检验以下假设:
尾侧RVL中一组特殊神经元的兴奋
(B)这些RVLc升高大脑皮层中的rCBF;
神经元被FN、NTS和氧反射性地兴奋
RVL吻侧敏感神经元(RVLr);(c)通往
RVLc的皮质是间接的,通过皮质下
投射可能局限于Z1;(d)
Z1神经元RVLc的兴奋依赖于
皮质神经元升高rCBF的最终表达;(e)
在RVL中代表的血管舒张通路是常见的
FN、NTS和RVLr的激活也通过该途径
导致脑电图减慢和局部脑血流量升高 研究
将首次提供证据证明
脑干连接内脏传入活动与循环,
脑电活动
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
EUGENE V GOLANOV其他文献
EUGENE V GOLANOV的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('EUGENE V GOLANOV', 18)}}的其他基金
REGULATION OF CEREBRAL BLOOD FLOW BY THE ROSTRAL VENTROLATERAL MEDULLA
头端腹外侧延髓对脑血流的调节
- 批准号:
6354108 - 财政年份:2000
- 资助金额:
$ 11.7万 - 项目类别:
REGULATION OF CEREBRAL BLOOD FLOW BY THE ROSTRAL VENTROLATERAL MEDULLA
头端腹外侧延髓对脑血流的调节
- 批准号:
6109475 - 财政年份:1999
- 资助金额:
$ 11.7万 - 项目类别:
REGULATION OF CEREBRAL BLOOD FLOW BY THE ROSTRAL VENTROLATERAL MEDULLA
头端腹外侧延髓对脑血流的调节
- 批准号:
6296851 - 财政年份:1999
- 资助金额:
$ 11.7万 - 项目类别:
REGULATION OF CEREBRAL BLOOD FLOW BY THE ROSTRAL VENTROLATERAL MEDULLA
头端腹外侧延髓对脑血流的调节
- 批准号:
6272561 - 财政年份:1998
- 资助金额:
$ 11.7万 - 项目类别:
Regulation of CBF by the Rostral Ventrolateral Medulla
头端腹外侧延髓对 CBF 的调节
- 批准号:
6605765 - 财政年份:1997
- 资助金额:
$ 11.7万 - 项目类别:
相似海外基金
Comparative Study of Brain Circulation of Higher Education in the Corona Era-Towards New Model
新冠时代高等教育人才循环比较研究——迈向新模式
- 批准号:
21H00881 - 财政年份:2021
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Brain circulation based on a change of the rSO2 in patients with cardiopulmonary arrest in the pre-hospital settings.
基于院前心肺骤停患者 rSO2 变化的脑循环。
- 批准号:
19H03758 - 财政年份:2019
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Continuum biomechanics of the whole brain circulation for the computational analysis of cerebrovascular diseases
用于脑血管疾病计算分析的全脑循环连续体生物力学
- 批准号:
19H01175 - 财政年份:2019
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development Research of Brain Circulation Program based on Comparative Study of Globally Compatible STEM Higher Education
基于全球兼容STEM高等教育比较研究的脑循环计划发展研究
- 批准号:
17H01986 - 财政年份:2017
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Empirical Study on the Brain Circulation of International Students with Science and Engineering Majors
理工科专业留学生大脑循环的实证研究
- 批准号:
15K04351 - 财政年份:2015
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Elucidation of blood flow control mechanisms for establishing a wide area of simulator of brain circulation after cerebral revascularization
阐明脑血运重建后大面积脑循环模拟器的血流控制机制
- 批准号:
15H04952 - 财政年份:2015
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
elucidation of the brain circulation during prehospital resuscitation
阐明院前复苏期间的脑循环
- 批准号:
15H05007 - 财政年份:2015
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Systematic study on brain circulation during anaphylactic shock
过敏性休克时脑循环的系统研究
- 批准号:
25462839 - 财政年份:2013
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Relationships between brain circulation and career development among Indonesian nurses who worked in Japan
赴日印尼护士脑循环与职业发展的关系
- 批准号:
24659958 - 财政年份:2012
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Elucidation of the brain circulation during resuscitation.
阐明复苏期间的脑循环。
- 批准号:
24390401 - 财政年份:2012
- 资助金额:
$ 11.7万 - 项目类别:
Grant-in-Aid for Scientific Research (B)