INFANT HEME CATABOLISM AND CARBON MONOXIDE DETECTION

婴儿血红素分解代谢和一氧化碳检测

• 批准号: 6219297
• 负责人: DAVID K STEVENSON
• 金额: $ 0.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219297
• 关键词: bilirubin; biotransformation; blood disorder diagnosis; breath tests; carbon monoxide; clinical research; diagnosis design /evaluation; hemolysis; human subject; infant human (0-1 year); noninvasive diagnosis; patient monitoring device

We continue our development of carbon monoxide (CO) -monitoring technology for laboratory and bedside diagnosis of hemolysis of increased total bilirubin production from other causes. This involves developing and refining instrumentation and techniques for the measurement of excreted CO. These efforts, in cooperation with Natus Medical, Inc. San Carlos, CA, have resulted in the production of a portable, non-invasive instrument for the bedside monitoring of end-tidal breath CO as an index of bilirubin production for all causes. Recently, high intensity light-emitting diodes(LEDs) have been studied as possible light sources for the phototherapy of hyperbilirubinemia. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin.

我们继续开发一氧化碳（CO）监测技术，用于实验室和床旁诊断其他原因引起的总胆红素产生增加的溶血。这涉及开发和改进用于测量排出的CO的仪器和技术。San卡洛斯，CA，已经生产出一种便携式、非侵入式仪器，用于床旁监测潮气末呼吸CO，作为所有原因的胆红素产生的指标。最近，高强度发光二极管（LED）已被研究作为可能的光源，用于高胆红素血症的光疗。 这些功率高效、低发热的光源具有在可见光谱的蓝绿色部分中递送窄波长带的高强度光的潜力，该可见光谱的蓝绿色部分与胆红素的吸收光谱重叠。