A nanomedicine strategy for detecting and modulating protease activity in vivo

用于检测和调节体内蛋白酶活性的纳米医学策略

• 批准号: nhmrc : 1024723
• 负责人: Prof Denis Wakefield
• 金额: $ 30.38万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nanomedicine-strategy-detecting-activity-vivo/110369
• 关键词: nanomedicine; strategy; detecting; modulating; protease

Protease enzymes are vitally important for normal bodily function but can play a deleterious role in many diseases such as cancer, aging diseases and eye diseases. The proposed research will provide a nanomedicine solution to the detection and therapeutic control of protease activity in vivo using nanoporous optical devices that are benign to the body. This general strategy for will be demonstrated in eyes with a view to detection and treating the eye disease uveitis.

蛋白酶对正常的身体功能至关重要，但在癌症、老年病和眼科疾病等许多疾病中也会起到有害的作用。这项拟议的研究将提供一种纳米医学解决方案，使用对人体无害的纳米多孔光学设备来检测和治疗体内的蛋白酶活性。这一治疗的一般策略将在眼睛中进行演示，以期检测和治疗眼部疾病葡萄膜炎。