Studies on the pathogenesis of human pterygia

人类翼状胬肉发病机制的研究

• 批准号: nhmrc : 113905
• 负责人: Prof Denis Wakefield
• 金额: $ 13.67万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studies-pathogenesis-human-pterygia/97410
• 关键词: Studies; pathogenesis; human; pterygia

Pterygia, one of the most common ocular complaints in Australia and worldwide, are thought to originate from overexposure to UV light. We propose that UV-irradiation stimulate certain cells in the eye to produce cytokines, growth factors and enzymes which degrade scaffold proteins such as collagens. These enzymes may play a key role in the progressive and invasive nature of pterygia. Dissecting the mechanism(s) by which UV light induces these proteins will lead to new and more reliable therapies for the treatment of pterygia.

翼状胬肉是澳大利亚和全世界最常见的眼部疾病之一，被认为是由于过度暴露于紫外线。我们提出紫外线照射刺激眼睛中的某些细胞产生细胞因子，生长因子和降解支架蛋白如胶原蛋白的酶。这些酶可能在翼状胬肉的进行性和侵袭性中起关键作用。剖析紫外线诱导这些蛋白质的机制将导致治疗翼状胬肉的新的和更可靠的疗法。