Toll like receptors in ocular inflammation

眼部炎症中的 Toll 样受体

• 批准号: nhmrc : 455321
• 负责人: Prof Denis Wakefield
• 金额: $ 19.2万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/toll-like-receptors-ocular-inflammation/96804
• 关键词: Toll; like; receptors; ocular; inflammation

The aim of this project is to better understand the events that cause the onset of uveitis, a common cause of visual impairment and blindness in adults. Toll like receptors (TLR) are a new group of cell surface receptors tinflammatory mediators.hat are important in immune function and the immune system's ability to recognise and respond to to microbes by recognising signature molecules contained in microbes. The TLR system is the early warning system of immune defence and activation of the TLR system induces the generation of multiple mediators that initiate and perpetuate inflammation. There has been intense interest and research into this novel family of receptors and they have been shown to play an important role in human diseases such as inflammatory bowel disease and psoriasis. The role of TLRs in uveitis has not been studied. We hypothesise that TLRs play a central role linking certain bacteria and the induction of uveitis. TLR4, a member of the TLR family has been clearly identified as the key receptor for cell wall components of gram negative bacteria (a chemical called LPS). In vitro data shows that TLR4 stimulation by LPS causes the release of inflammatory mediators. This project is designed to study the expression of TLRs in the eye, factors that control their expression and the results of stimultaing TLRs with their target chemicals. Better understanding ofd the causes and mechanisms of uveitis will allow the development of more specific and effective treatments.

该项目的目的是为了更好地了解导致葡萄膜炎发病的事件，葡萄膜炎是成年人视力损害和失明的常见原因。Toll样受体（Toll like receptor， TLR）是一类新的细胞表面受体和炎症介质。帽子在免疫功能和免疫系统通过识别微生物中包含的特征分子来识别和响应微生物的能力中很重要。TLR系统是免疫防御的早期预警系统，TLR系统的激活诱导多种介质的产生，从而引发和延续炎症。人们对这一新的受体家族有着浓厚的兴趣和研究，它们已被证明在炎症性肠病和牛皮癣等人类疾病中发挥重要作用。tlr在葡萄膜炎中的作用尚未被研究。我们假设tlr在连接某些细菌和诱导葡萄膜炎方面起着核心作用。TLR4是TLR家族的一员，已被明确确定为革兰氏阴性菌细胞壁成分（一种称为LPS的化学物质）的关键受体。体外实验数据显示，LPS刺激TLR4可引起炎症介质的释放。本项目旨在研究眼部tlr的表达、控制其表达的因素以及用其靶化学物质刺激tlr的结果。更好地了解葡萄膜炎的原因和机制将有助于开发更具体和有效的治疗方法。