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Ultraviolet-induced effector molecules in ocular surface diseases: regulation of expression in vitro and in vivo

眼表疾病中紫外线诱导的效应分子：体外和体内表达的调节

基本信息

批准号：
nhmrc : 350919
负责人：
Prof Denis Wakefield
金额：
$ 19.57万
依托单位：
The University of New South Wales
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2005
资助国家：
澳大利亚
起止时间：
2005-01-01 至 2006-12-31
项目状态：
已结题

来源：
https://researchdata.edu.au/ultraviolet-induced-effector-vitro-vivo/99187
关键词：
Ultraviolet induced effector molecules ocular

项目摘要

Pterygium is a common, recurrent, inflammatory, and sight-threatening complication of the human eye. The disease is characterised by a fleshy vascular growth that gradually covers the ocular surface if left untreated. Limbal dysplasia is a less common disease but in some regards this disease behaves much like a pterygium. We have generated considerable laboratory based data that these ocular surface disorders may be triggered by ultraviolet (UV) radiation and this fits well with the extensive epidemiological evidence. To data the only form of treatment is surgical intervention, often with adjunctive topical agents that can cause other more severe complication of the eye. The aim of this investigation is to determine the effectiveness of agents such as retinoic acid and interferons to block or inhibit the down-stream effects of UV radiation. Currently, we have preliminary data that suggests these agents can significantly reduce several molecules that are activated by UV in cultured ocular surface cells. Furthermore, we have clinical evidence that retinoic acid and interferon can resolve both pterygia and conjunctival dysplasia in a small group of patients. If successful, these agents may replace costly and time-consuming surgical approach to treatment.

翼状胬肉是一种常见的、复发性的、炎症性的、威胁视力的人眼并发症。这种疾病的特征是肉质血管生长，如果不及时治疗，会逐渐覆盖眼表。边缘发育不良是一种不太常见的疾病，但在某些方面，这种疾病的表现很像翼状胬肉。我们已经获得了大量基于实验室的数据，表明这些眼表疾病可能是由紫外线辐射引发的，这与广泛的流行病学证据非常吻合。数据显示，唯一的治疗形式是手术干预，通常使用辅助局部药物，可引起其他更严重的眼部并发症。本研究的目的是确定维甲酸和干扰素等药物阻断或抑制紫外线辐射下游效应的有效性。目前，我们有初步的数据表明，这些药物可以显著减少培养的眼表细胞中被紫外线激活的几种分子。此外，我们有临床证据表明维甲酸和干扰素可以解决一小部分患者的翼状胬肉和结膜发育不良。如果成功，这些药物可以取代昂贵和耗时的手术治疗方法。