Mapping the dynamics of corneal stem cell during aging and after wounding and transplantation

绘制衰老过程中以及受伤和移植后角膜干细胞的动态图

• 批准号: nhmrc : GNT1101078
• 负责人: Prof Denis Wakefield
• 金额: $ 54.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mapping-dynamics-corneal-wounding-transplantation/1346145
• 关键词: Mapping; dynamics; corneal; stem; cell

Restoring vision in patients with corneal blindness is our focus. Before this can be achieved we need to understand how corneal stem cells function. For many reasons these studies cannot be performed in man, so we engineered a mouse in which the location, migration, division, differentiation, death of these cells can be followed indefinitely. This information will allow us to improve current therapeutic options and develop new clinical solution for patients with blinding corneal disease.

恢复角膜盲患者的视力是我们的重点。在此之前，我们需要了解角膜干细胞的功能。由于许多原因，这些研究无法在人体中进行，因此我们设计了一种小鼠，可以无限期地跟踪这些细胞的定位，迁移，分裂，分化和死亡。这些信息将使我们能够改善目前的治疗方案，并为致盲性角膜疾病患者开发新的临床解决方案。