DISPOSITION OF DAPSONE

本研究将研究氨苯砜在体内的处置，以通过替代代谢途径表征代谢。 目的是确定在人体内氨苯砜的总体消除中每种代谢途径的相对重要性。 通过使用不同试剂对特定代谢酶的选择性调节，将评价参与这些反应的酶及其对这些代谢物形成的相对贡献。 本研究将在50名正常健康志愿者中进行。

This study will investigate the disposition of dapsone in vivo to characterize metabolism by alternative routes of metabolism. The objective is to determine the relative importance of each route of metabolism in the overall elimination of dapsone in humans. By using selective modulation of specific metabolizing enzymes by different agents, the enzymes that are involved in these reactions and their relative contributions to the formation of these metabolites will be evaluated. The study will be conducted in 50 normal healthy volunteers.