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SELECTIVE MODULATION OF ESTROGEN METABOLIC PATHWAYS

SELECTIVE MODULATION OF ESTROGEN METABOLIC PATHWAYS
选择性调节雌激素代谢途径
批准号：
6275833
负责人：
ADEDAYO ADEDOYIN
金额：
$1.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275833
关键词：
breast neoplasms cancer risk clinical research enzyme activity estrogens genetic polymorphism genetic susceptibility hormone metabolism human subject neoplasm /cancer genetics oncogenes

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中文摘要
翻译
雌激素与乳腺癌的发病率有关。这可能
英文摘要
Estrogen has been implicated in the incidence of breast cancer. This could be due to the profile and level of different estrogens in the body which are controled by its metabolism by alternative pathways. The inter- individual differences in the expression & activity of the enzymes involved in this metabolism can therefore act as susceptibility risk factor for breast cancer. Consequently, modulation of estrogen metabolism to favorably alter the profile & level of estrogens in the body can be used as a mgmt strategy. This project will investigate this ability.
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DISPOSITION OF DAPSONE
DEVELOPMENT OF FLURBIPROFEN AS A SELECTIVE PROBE OF CYP2C9
SPECIFICITY OF THE ACTIVITIES OF DIFFERENT MODULATING AGENTS
DEVELOPMENT OF FLURBIPROFEN AS A SELECTIVE PROBE OF CYP2C9
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