SELECTIVE MODULATION OF ESTROGEN METABOLIC PATHWAYS

雌激素与乳腺癌的发病率有关。这可能 是由于不同的雌激素在体内的概况和水平， 都是由它的新陈代谢控制的。间- 酶的表达和活性的个体差异 因此，参与这种代谢的人可以作为易感性风险 乳腺癌的危险因素。因此，调节雌激素代谢 为了有利地改变体内雌激素的分布和水平， 作为一种管理策略。本项目将研究这种能力。

Estrogen has been implicated in the incidence of breast cancer. This could be due to the profile and level of different estrogens in the body which are controled by its metabolism by alternative pathways. The inter- individual differences in the expression & activity of the enzymes involved in this metabolism can therefore act as susceptibility risk factor for breast cancer. Consequently, modulation of estrogen metabolism to favorably alter the profile & level of estrogens in the body can be used as a mgmt strategy. This project will investigate this ability.