CYTOKINE CASCADE IN BLOOD & CENTRAL NERVOUS SYSTEM

目的探讨细胞因子对血管活性物质释放的影响。 外周血和鞘内的可溶性介质 车厢。结果白介素1(IL-1)等细胞因子 内源性细胞因子释放的有效刺激因子和 神经内分泌轴，因此在 免疫系统和大脑之间的通讯。我们一直在 研究IL-1对其他细胞因子的影响，如 白细胞介素6，在外周血液和鞘内隔室。 在我们证明IL-6从体内释放出来之后 在中枢神经系统内，我们一直在研究初级细胞 消息来源。这项研究的重点是血管内皮细胞。 血脑屏障。此外，我们一直在调查 皮质类固醇在多大程度上参与调节这些 促炎症反应，这与类固醇的作用有关 败血症和过敏性休克。我们未来的研究方向是 现在关注的是血脑屏障的内皮细胞。为了这个 项目，我们已经建立了内皮细胞培养，将 允许对血脑屏障的体外模型进行研究。 关键词细胞因子、白介素1、白介素6脑脊液 心理神经免疫学基金NIMH学位论文奖，NSF博士前 研究员，NIMH MH41659，Reyes，T.M.和Coe，C.L.1998。 中枢神经系统和血液中的促炎细胞因子网络相互作用 关于恒河猴的。《美国生理学杂志》43 R139-149。 雷耶斯，T.M.和科，C.L.1998。中枢神经系统的阻力 猴白细胞介素6系统对糖皮质激素的抑制作用。 《美国生理学杂志》44 R612-618。

OBJECTIVES To examine the influence of cytokines on the release of soluble mediators in the peripheral blood and intrathecal compartments. RESULTS Cytokines, such as interleukin-1 (IL-1), are potent stimulators of endogenous cytokine release and the neuroendocrine axis, and thus play an important role in the communication between the immune system and the brain. We have been investigating the influence of IL-1 on other cytokines, such as interleukin-6, in the peripheral blood and intrathecal compartments. Following our demonstration that IL-6 is released endogenously from within the CNS, we have been investigating the primary cellular source. This research has focused on the endothelial cells of the blood-brain-barrier. In addition, we have been investigating the degree to which corticosteroids are involved in modulating these proinflammatory responses, which has bearing on the role of steroids in sepsis and anaphylactic shock. FUTURE DIRECTIONS Our studies are now focused on endothelial cells of the blood-brain-barrier. For this project, we have established endothelial cell cultures that will permit the research to go forward with in vitro models of the BBB. KEY WORDS cytokines, interleukin-1, interleukin-6 cerebrospinal fluid, psychoneuroimmunology FUNDING NIMH Dissertation Award, NSF Predoctoral fellowship, NIMH MH41659 PUBLICATIONS Reyes, T.M. and Coe, C.L. 1998. The proinflammatory cytokine network Interactions in the CNS and blood of rhesus monkeys. American Journal of Physiology 43 R139-149. Reyes, T.M. & Coe, C.L. 1998. Resistance of the central nervous system interleukin-6 to glucocorticoid inhibition in monkeys. American Journal of Physiology 44 R612-618.