MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND

褪黑素治疗盲人昼夜节律睡眠障碍

• 批准号: 6116987
• 负责人: ROBERT L SACK
• 金额: $ 3.13万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116987
• 关键词: alternative medicine; blindness; circadian rhythms; clinical research; clinical trials; hormone therapy; human subject; human therapy evaluation; melatonin; oral administration; sleep disorders

Totally blind people have sleep problems that are caused by desynchronized circadian rhythms. Without photic time cues, the internal body clock tends to "free-run" on about a 24.5 cycle; as a result, circadian rhythms move in and out of phase with desired sleep times, causing recurrent insomnia and impaired daytime alertness. Melatonin has been designated as an orphan drug for the treatment of circadian rhythm sleep disorders in blind people with no light perception. Nightly oral administration of melatonin may act as a "darkness signal" that can synchronize internal rhythms to desired sleep times. In addition to this "clock resetting" (phase shifting) action, melatonin may benefit insomnia in blind patients by a direct sleep-promoting (sedative) action.

完全失明的人有睡眠问题，这些问题是由不同步引起的 昼夜节律。如果没有光时间提示，体内的生物钟 倾向于在大约24.5个周期上自由奔跑；结果，昼夜节律 与所需的睡眠时间同步和不同步，导致反复出现 失眠和白天警觉受损。褪黑素已被指定为 一种治疗昼夜节律睡眠障碍的孤儿药物 没有光觉的盲人。每晚口服给药 褪黑素可能起到“黑暗信号”的作用，它可以使体内 将节奏调整到理想的睡眠时间。除了这种“时钟重置” (相移)作用，褪黑素可能有益于失眠失眠患者 通过直接促进睡眠(镇静)的作用。