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MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND

MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND
褪黑素治疗盲人昼夜节律睡眠障碍
批准号：
6278182
负责人：
ROBERT L SACK
金额：
$2.86万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6278182
关键词：
alternative medicine blindness circadian rhythms clinical research clinical trials hormone therapy human subject human therapy evaluation melatonin oral administration sleep disorders

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英文摘要
Totally blind people have sleep problems that are caused by desynchronized circadian rhythms. Without photic time cues, the internal body clock tends to "free-run" on about a 24.5 cycle; as a result, circadian rhythms move in and out of phase with desired sleep times, causing recurrent insomnia and impaired daytime alertness. Melatonin has been designated as an orphan drug for the treatment of circadian rhythm sleep disorders in blind people with no light perception. Nightly oral administration of melatonin may act as a "darkness signal" that can synchronize internal rhythms to desired sleep times. In addition to this "clock resetting" (phase shifting) action, melatonin may benefit insomnia in blind patients by a direct sleep-promoting (sedative) action.
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Minimal effective melatonin dose for circadian entrainment in blind people
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