MUCOSAL PROTEIN SYNTHESIS IN TYPE I DIABETES MELLITUS

本研究的目的是更好地了解胰岛素缺乏如何影响I型糖尿病患者肠道蛋白的代谢。1型糖尿病是一种蛋白质分解代谢状态。先前的研究结果表明，蛋白质周转的急性变化发生在肌肉以外的部位。基于内脏的研究，很可能是在粘膜蛋白中发生了蛋白质周转的急性变化。本研究已停止登记。生物医学质谱中心的样品分析仍在继续。

The purpose of this study is to better understand how lack of insulin affects the metabolism of intestinal proteins in patients with type I diabetes. Type I diabetes is a protein catabolic state. Findings from previous studies suggest that the acute change in protein turnover are occurring at a site other than muscle. Based on splanchnic studies, it is likely that the acute changes in protein turnover are occurring in the mucosal proteins. Enrollment is closed for this study. Sample analysis in the Biomedical Mass Spectrometry Core continues.