EFFECT OF CIRRHOSIS ON PROTEIN METABOLISM

肝硬化对蛋白质代谢的影响

• 批准号: 6117368
• 负责人: M CHARLTON
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117368
• 关键词: clinical research; human subject; human therapy evaluation; liver cirrhosis; liver transplantation; protein metabolism

People with cirrhosis have a tendency to break down their stores of protein. The degree to which this occurs affects the rates of several complications of cirrhosis, including infection and bleeding into the gastrointestinal tract as well as survival after liver transplantation. The reason for this loss of protein stores is not known. An invariable finding in cirrhosis is an excess of the hormone glucagon. There is some evidence that glucagon causes protein breakdown. The purposes of this study are to determine the effect of cirrhosis on the metabolism of protein in the body, and to determine whether the changes in protein metabolism in cirrhosis are due to an excess of the hormone glucagon. Nine participants have completed the study. Although there was no patient activity during the last reporting period, analysis of samples in the Biomedical Mass Spectrometry Core continues.

患有肝硬变的人倾向于分解他们储存的蛋白质。发生这种情况的程度会影响几种肝硬变并发症的发生率，包括感染、胃肠道出血以及肝移植后的存活率。蛋白质储备减少的原因尚不清楚。在肝硬变中，一个不变的发现是激素胰高血糖素过量。有证据表明，胰高血糖素会导致蛋白质分解。本研究的目的是确定肝硬变对体内蛋白质代谢的影响，并确定肝硬变时蛋白质代谢的变化是否是由于激素胰高血糖素过多所致。九名参与者已经完成了这项研究。尽管在上一次报告所述期间没有病人活动，但对生物医学质谱仪核心样品的分析仍在继续。