EFFECT OF CIRRHOSIS ON PROTEIN METABOLISM

肝硬化患者容易分解体内储存的蛋白质。这种情况发生的程度影响肝硬化的几种并发症的发生率，包括感染和胃肠道出血以及肝移植后的生存率。蛋白质储存减少的原因尚不清楚。肝硬化的一个不变的发现是胰高血糖素过量。有证据表明胰高血糖素会导致蛋白质分解。本研究的目的是确定肝硬化对体内蛋白质代谢的影响，并确定肝硬化中蛋白质代谢的变化是否由于胰高血糖素激素过量所致。9名参与者已经完成了这项研究。虽然在上一个报告期间没有患者活动，但生物医学质谱中心的样品分析仍在继续。

People with cirrhosis have a tendency to break down their stores of protein. The degree to which this occurs affects the rates of several complications of cirrhosis, including infection and bleeding into the gastrointestinal tract as well as survival after liver transplantation. The reason for this loss of protein stores is not known. An invariable finding in cirrhosis is an excess of the hormone glucagon. There is some evidence that glucagon causes protein breakdown. The purposes of this study are to determine the effect of cirrhosis on the metabolism of protein in the body, and to determine whether the changes in protein metabolism in cirrhosis are due to an excess of the hormone glucagon. Nine participants have completed the study. Although there was no patient activity during the last reporting period, analysis of samples in the Biomedical Mass Spectrometry Core continues.