VLDL APO-B-100 SYNTHESIS IN NON-ALCOHOLIC STEATOHEPATITIS

非酒精性脂肪性肝炎中 VLDL APO-B-100 的合成

• 批准号: 6117436
• 负责人: M CHARLTON
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117436
• 关键词: apolipoprotein B; blood lipoprotein biosynthesis; clinical research; hepatitis; human subject; liver metabolism; very low density lipoprotein

The overall aim of this project is to determine the pathophysiology of non-alcoholic steatohepatitis (NASH) and specifically to determine whether the hepatic synthesis of VLDL apoB-100 is attenuated in patients with NASH, causing defective removal of synthesized triglycerides from hepatocytes. The specific aim is to measure the postabsorptive fractional synthesis rate of VLDL apoB-100 in subjects with histologically proven NASH and to compare this to the FSR of VLDL apo-B 100 in two control groups: 1) an equal number of body mass index, gender, and age-matched healthy subjects without NASH; and 2) an equal number of lean, gender and age-matched healthy control subjects without NASH.

该项目的总体目的是确定非酒精性脂肪性肝炎（NASH）的病理生理学，特别是确定NASH患者肝脏中VLDL apoB-100的合成是否减弱，从而导致肝细胞中合成甘油三酯的清除缺陷。具体目的是测量经组织学证实的NASH患者中VLDL - apoB-100的吸收后分数合成率，并将其与两个对照组中VLDL - apoB-100的FSR进行比较：1)相同数量的体重指数、性别和年龄匹配的无NASH健康受试者；2)等量的精瘦、性别和年龄匹配的无NASH的健康对照。