VLDL APO-B-100 SYNTHESIS IN NON-ALCOHOLIC STEATOHEPATITIS

该项目的总体目标是确定非酒精性脂肪性肝炎(NASH)的病理生理学，特别是确定NASH患者肝脏中VLDL apoB-100的合成是否减弱，导致合成的甘油三酯从肝细胞中清除有缺陷。具体目的是测量经组织学证实的NASH患者的VLDL apoB-100的吸收后分数合成率，并将其与两个对照组的VLDL apo-B 100的FSR进行比较：1)没有NASH的相同数量的体重指数、性别和年龄匹配的健康受试者；以及2)相同数量的瘦的、性别和年龄匹配的没有NASH的健康受试者。

The overall aim of this project is to determine the pathophysiology of non-alcoholic steatohepatitis (NASH) and specifically to determine whether the hepatic synthesis of VLDL apoB-100 is attenuated in patients with NASH, causing defective removal of synthesized triglycerides from hepatocytes. The specific aim is to measure the postabsorptive fractional synthesis rate of VLDL apoB-100 in subjects with histologically proven NASH and to compare this to the FSR of VLDL apo-B 100 in two control groups: 1) an equal number of body mass index, gender, and age-matched healthy subjects without NASH; and 2) an equal number of lean, gender and age-matched healthy control subjects without NASH.