MUCOSAL PROTEIN SYNTHESIS IN TYPE I DIABETES MELLITUS

I 型糖尿病的粘膜蛋白合成

• 批准号: 6278594
• 负责人: M CHARLTON
• 金额: $ 2.03万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278594
• 关键词: clinical research; hormone regulation /control mechanism; human subject; insulin; insulin dependent diabetes mellitus; intestinal mucosa; protein biosynthesis

The purpose of this study is to better understand how lack of insulin affects the metabolism of intestinal proteins in patients with type I diabetes. Type I diabetes is a protein catabolic state. Findings from previous studies suggest that the acute change in protein turnover are occurring at a site other than muscle. Based on splanchnic studies, it is likely that the acute changes in protein turnover are occurring in the mucosal proteins.

本研究的目的是更好地了解胰岛素缺乏是如何 影响I型糖尿病患者肠道蛋白质的代谢 糖尿病 I型糖尿病是一种蛋白质分解代谢状态。 的结果 以前的研究表明，蛋白质周转的急剧变化是 发生在肌肉以外的部位。 根据内脏研究， 蛋白质周转的急剧变化可能发生在 粘膜蛋白。