INTENSIVE INSULIN THERAPY IN HISPANICS WITH TYPE 2 DIABETES MELLITUS

糖尿病在女性中对心血管危险因素的影响程度大于男性，这解释了性别不能预测糖尿病患者心血管疾病的发生。 改善女性糖尿病患者的血糖控制与改善男性糖尿病患者的血糖控制相比，更能降低心血管危险因素。本研究的目的是：1）确定在用强化胰岛素治疗改善血糖控制并在长时间内维持正常血糖后，是否消除了先前报道的西班牙裔2型糖尿病患者血脂谱的任何性别差异; 2）确定是否用强化胰岛素治疗改善血糖控制，并且维持2年将改善2型糖尿病个体中CVD的经典和非经典危险因素，也就是说，如果这些因素可以在严格血糖控制的情况下改变。

Diabetes mellitus worsens cardiovascular risk factors to a greater extent in women than in men, explaining the failure of gender to predict the onset of cardiovascular disease among diabetic inficiduals. Improving glycemic control in diabetic women will be associated with greater reduction in cardiovascular risk factors than improved glycemic control in diabetic men. The aims of this study are 1) to determine if after improving glycemic control with intensive insulin treatment, and maintaining normoglycemia during a long period of time abolishes any gender differences in lipid profile previously reported in Hispanics with type 2 diabetes and 2) to determine whether improving glycemic control with intensive insulin therapy, and maintaining it for a two-year-period will improve both classical and non-classical risk factors for CVD in Type 2 diabetic individuals, that is, if these factors can be modified in the presence of strict glycemic control.