INTENSIVE INSULIN THERAPY IN HISPANICS WITH TYPE 2 DIABETES MELLITUS

西班牙裔 2 型糖尿病患者的强化胰岛素治疗

• 批准号: 6414499
• 负责人: Maines L Aviles-Santa
• 金额: $ 32.14万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6414499
• 关键词: INTENSIVE; INSULIN; THERAPY; HISPANICS; TYPE

Diabetes mellitus worsens cardiovascular risk factors to a greater extent in women than in men, explaining the failure of gender to predict the onset of cardiovascular disease among diabetic individuals. Improving glycemic control in diabetic women will be associated with greater reduction in cardiovascular risk factors than improved glycemic control in diabetic men.The aims of this study are 1) to determine if after improving glycemic control with intensive insulin treatment, and maintaining normoglycemia during a long period of time abolishes any gender differences in lipid profile previously reported in Hispanics with type 2 diabetes and 2) to determine whether improving glycemic control with intensive insulin therapy, and maintaining it for a two- year-period will improve both classical and non-classical risk factors for CVD in Type 2 diabetic individuals, that is, if these factors can be modified in the presence of strict glycemic control.

糖尿病使心血管危险因素恶化到更大程度 女性的程度高于男性，这解释了性别无法预测的原因 糖尿病患者心血管疾病的发病。 改善糖尿病女性的血糖控制与 与改善血糖相比，心血管危险因素的减少更大 糖尿病男性的控制。本研究的目的是 1) 确定是否 通过强化胰岛素治疗改善血糖控制后，以及 长期维持正常血糖可以消除任何 先前报道的西班牙裔血脂状况存在性别差异 患有 2 型糖尿病和 2) 确定是否改善血糖 通过强化胰岛素治疗来控制病情，并维持两年 年期间将改善经典和非经典风险因素 对于 2 型糖尿病患者的 CVD，也就是说，如果这些因素可以 在严格血糖控制的情况下进行修改。