CARDIAC RISK FACTORS IN HISPANICS WITH TYPE 2 DIABETES

心血管疾病(CVD)是这两种疾病的最常见原因 以及2型糖尿病患者的死亡率。糖尿病女性已经表现出 心血管疾病死亡率与糖尿病男性相当， 无论年龄大小。显然，雌激素的“保护性”作用 在非糖尿病妇女中观察到的情况在糖尿病妇女中没有观察到。 拉美裔美国人的心血管疾病发病率不断上升，几乎 这些都是由糖尿病引起的。控制不善的西班牙裔女性 已经发现，2型糖尿病具有更强的动脉粥样硬化 与西班牙裔糖尿病男性和非糖尿病男性相比，他们的血脂水平更高。有多少 这些异常是可逆的，糖尿病的控制尚不清楚。 严格控制血糖对心血管疾病发展的益处 2型糖尿病患者尚未确诊。更正 当高血糖发生时，就会出现脂代谢异常 改进了。然而，慢性高血糖与糖尿病的关系 心血管疾病的其他危险因素显示在糖尿病中起作用 (脂蛋白(A)、血浆同型半胱氨酸和抗氧化剂) 描述。 这项研究将检验这一假设，即西班牙裔女性患有不良 控制2型糖尿病将导致心血管疾病的更大改善 比改善血糖控制更危险的因素对患有不良的西班牙裔男性的影响 控制住了糖尿病。这些风险因素及其改善 糖尿病控制将在3年内进行监测。如果太紧 血糖控制恢复了心血管危险因素的性别差异，这 这项研究可能会对糖尿病的治疗产生重大影响 女人。

Cardiovascular disease (CVD) is the most common cause of both morbidity and mortality in Type 2 diabetic individuals. Diabetic women have shown to have a comparable incidence of CVD mortality with diabetic men, regardless of age. Apparently, the "protective" effects of estrogen observed in non-diabetic women are not observed in diabetic women. Hispanics have shown an increasing incidence rate of CVD that is nearly all accounted for by diabetes. Hispanic women with poorly controlled Type 2 diabetes mellitus have been found to have a more atherogenic lipid profile than Hispanic diabetic and non-diabetic men. How much of these abnormalities are reversible with control of diabetes is unknown. The benefits of strict glycemic control on the development of CVD in persons with Type 2 diabetes have not been established. Correction of lipid metabolic abnormalities has been seen when hyperglycemia is improved. However, the relationship between chronic hyperglycemia and other risk factors for CVD shown to be operative in diabetes mellitus (lipoprotein (a), plasma homocysteine and antioxidants) has not been described. This study will test the hypothesis that Hispanic women with poorly controlled Type 2 diabetes will result in a greater improvement in CVD risk factors than improved glycemic control in Hispanic men with poorly controlled diabetes. These risk factors and their improvement with diabetes control will be monitored over a 3-year period. If tight glycemic control restores gender differences in CVD risk factors, this study could have great implications regarding the treatment of diabetic women.