西班牙裔 2 型糖尿病患者的强化胰岛素治疗-猫眼课题宝

西班牙裔 2 型糖尿病患者的强化胰岛素治疗

批准号：

6278794

负责人：

Maines L Aviles-Santa

金额：

$2.47万

依托单位：

UT SOUTHWESTERN MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

1997

资助国家：

美国

项目状态：

已结题

起止时间：

1997-12-01 至 1998-11-30

来源：

https://reporter.nih.gov/project-details/6278794

关键词：

Hispanic Americans blood glucose blood lipid cardiovascular disorder prevention clinical research diabetes mellitus therapy diabetic angiopathy disease /disorder proneness /risk female gender difference hormone therapy human data human therapy evaluation insulin longitudinal human study noninsulin dependent diabetes mellitus

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英文摘要

Diabetes mellitus worsens cardiovascular risk factors to a greater extent in women than in men, explaining the failure of gender to predict the onset of cardiovascular disease among diabetic individuals. Improving glycemic control in diabetic women will be associated with greater reduction in cardiovascular risk factors than improved glycemic control in diabetic men.The aims of this study are 1) to determine if after improving glycemic control with intensive insulin treatment, and maintaining normoglycemia during a long period of time abolishes any gender differences in lipid profile previously reported in Hispanics with type 2 diabetes and 2) to determine whether improving glycemic control with intensive insulin therapy, and maintaining it for a two- year-period will improve both classical and non-classical risk factors for CVD in Type 2 diabetic individuals, that is, if these factors can be modified in the presence of strict glycemic control.

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