CARDIAC RISK FACTORS IN HISPANICS WITH TYPE 2 DIABETES

西班牙裔 2 型糖尿病患者的心脏危险因素

• 批准号: 6176132
• 负责人: Maines L Aviles-Santa
• 金额: $ 11.72万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6176132
• 关键词: Hispanic Americans; antioxidants; atherosclerosis; blood chemistry; cardiovascular disorder epidemiology; clinical research; comorbidity; coronary disorder; diabetes mellitus therapy; disease /disorder proneness /risk; female; gender difference; glucose clamp technique; homocysteine; hormone therapy; human subject; human therapy evaluation; insulin; insulin sensitivity /resistance; longitudinal human study; noninsulin dependent diabetes mellitus; women's health

Cardiovascular disease (CVD) is the most common cause of both morbidity and mortality in Type 2 diabetic individuals. Diabetic women have shown to have a comparable incidence of CVD mortality with diabetic men, regardless of age. Apparently, the "protective" effects of estrogen observed in non-diabetic women are not observed in diabetic women. Hispanics have shown an increasing incidence rate of CVD that is nearly all accounted for by diabetes. Hispanic women with poorly controlled Type 2 diabetes mellitus have been found to have a more atherogenic lipid profile than Hispanic diabetic and non-diabetic men. How much of these abnormalities are reversible with control of diabetes is unknown. The benefits of strict glycemic control on the development of CVD in persons with Type 2 diabetes have not been established. Correction of lipid metabolic abnormalities has been seen when hyperglycemia is improved. However, the relationship between chronic hyperglycemia and other risk factors for CVD shown to be operative in diabetes mellitus (lipoprotein (a), plasma homocysteine and antioxidants) has not been described. This study will test the hypothesis that Hispanic women with poorly controlled Type 2 diabetes will result in a greater improvement in CVD risk factors than improved glycemic control in Hispanic men with poorly controlled diabetes. These risk factors and their improvement with diabetes control will be monitored over a 3-year period. If tight glycemic control restores gender differences in CVD risk factors, this study could have great implications regarding the treatment of diabetic women.

心血管疾病（CVD）是这两种疾病的最常见原因 2型糖尿病患者的死亡率。糖尿病女性显示 与男性糖尿病患者相比， 无论年龄。显然，雌激素的“保护”作用 在非糖尿病女性中观察到的，在糖尿病女性中未观察到。 西班牙裔显示CVD的发病率增加， 都是糖尿病引起的控制不良的西班牙裔女性 已经发现2型糖尿病具有更高的致动脉粥样硬化性， 血脂谱比西班牙裔糖尿病和非糖尿病男性。多少 这些异常在糖尿病控制下是否可逆尚不清楚。 严格控制血糖对心血管疾病发展的益处 2型糖尿病的发病率有哪些？校正 当高血糖症时， 提高然而，慢性高血糖症与 显示在糖尿病中起作用的CVD的其他风险因素 （脂蛋白（a），血浆同型半胱氨酸和抗氧化剂）尚未被 介绍了 这项研究将测试西班牙裔妇女与穷人的假设， 控制2型糖尿病将导致CVD的更大改善 在西班牙裔男性中， 控制糖尿病。这些危险因素及其改善， 将在3年期间监测糖尿病控制情况。如果紧 血糖控制恢复了CVD风险因素的性别差异， 这项研究可能对糖尿病的治疗有很大的影响。 妇女