STRUCTURE OF LARGE TERMINASE SUBUNIT FROM BACTERIOPHAGE T4: VIRUS ASSEMBLY

噬菌体 T4 大末端酶亚基的结构：病毒组装

• 批准号: 6120583
• 负责人: Venigalla B. Rao
• 金额: $ 0.34万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6120583
• 关键词: animal tissue; biomedical resource; infection; vaccines

This laboratory has been trying to determine the structure of retrovirus cores by cryoEM. They have been finding them to be somewhat heterogeneous and not icosahedral. They sent a sample to the STEM for mass analysis. It was very heterogeneous, with filled and empty capsids of different sizes, plus some tubes and sheets. Possibly a different preparation would be better. A new sample was more pure, but still appeared to have heterogeneous cores.

这个实验室一直在试图确定 通过cryoEM检测逆转录病毒核心。 他们发现 有些不均匀且不是二十面体。 他们把样本送到了 用于质量分析的STEM。 它非常异质，充满了， 不同大小的空衣壳，加上一些管和片。 也许另一种准备会更好。 一个新的样本是 更纯，但仍然表现出具有异质核。