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TNT THERAPY OF MALIGNANT GLIOMA

TNT THERAPY OF MALIGNANT GLIOMA
恶性胶质瘤的 TNT 治疗
批准号：
6265497
负责人：
SUNIL J PATEL
金额：
$1.74万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6265497
关键词：
antineoplastics clinical research dosage drug adverse effect drug screening /evaluation glioma human subject human therapy evaluation neoplasm /cancer chemotherapy pharmacokinetics

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英文摘要
Primary Objective: Determination of the miximum tolerated dose (MTD) or optimal biologic dose (OBD) of interstital 131 1-chINY-1/B in patient with recurrent supratentorial anaplastic astocytoma or glioblastoma mulitforme. Secondary Objectives: Determination of the safety of interstital 131 l-chTNT-1/B or renal, hepatic, hematologic, and biochemical profiles; Determination of the pharmacokinetic profile, demonstrated by total, free and bound iodine-131, of interstital 131 1-chTNTY-1/B presugically in six patients.
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