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PHASE II MULTICENTER TRIAL OF INTRATUMORAL/INTERSTITIAL THERAPY--BRAIN TUMORS

PHASE II MULTICENTER TRIAL OF INTRATUMORAL/INTERSTITIAL THERAPY--BRAIN TUMORS
瘤内/间质治疗的II期多中心试验——脑肿瘤
批准号：
6119064
负责人：
SUNIL J PATEL
金额：
$2.71万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6119064
关键词：
brain neoplasms clinical research diphtheria toxin drug administration routes drug screening /evaluation human subject human therapy evaluation immunotoxicity neoplasm /cancer chemotherapy neoplasm /cancer immunotherapy neurotoxicology transferrin

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中文摘要
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英文摘要
HN-66000 is a proprietary pharmaceutical formulation of mutant diptheria toxin (CRM 107) and human transferrin(Tf) that is being developed as a potential treat ment for malignant brain tumors. The results for a Phase I trial with HN-66000, sponsored by the NIH, suggest that HN-66000 produces tumor responses in patients with malignant brain tumors refractory to conventional therapy without severe neurologic or systemic toxicity. These encouraging results warrant an expanded evaluation of HN-66000 at other centers in a Phase II trial.
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