VASCULAR COMPRESSION OF THE MEDULLA OBLONGATA IN PTS WITH ESSENTIAL HYPERTENSION

原发性高血压患者延髓血管受压

• 批准号: 6119060
• 负责人: SUNIL J PATEL
• 金额: $ 1.74万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119060
• 关键词: blood pressure; clinical research; cranial nerves; essential hypertension; human subject; medulla oblongata; muscle tone; vagus nerve

Using magnetic resonance imaging (MRI) techniques, to show that patients with EHTN have a statistically significant increased incidence of vascular compression of the surface of the ventrolateral medulla at or near the entry zone of CNs IX and X, compared to age-matched normotensive individuals. Among patients with EHTN, to show an association between increased sympathetic outflow from the central nervous system and vascular compression of the medulla. To show the exact nature of this relationship: Left versus right medulla; the vessel involved; the type of compression (touching or indentation); the site of compression (along the IXth and Xth CNs)and/or their root entry zone, upper or lower medulla.

使用磁共振成像（MRI）技术表明，与年龄匹配的血压正常个体相比，EHTN患者在CN IX和X入口区或附近的腹外侧延髓表面血管压迫的发生率在统计学上显着增加。 在EHTN患者中，显示中枢神经系统交感神经流出增加与髓质血管压迫之间的相关性。 显示这种关系的确切性质：左侧与右侧髓质;涉及的血管;压迫类型（接触或压痕）;压迫部位（沿着第IX和第X CN）和/或其根部进入区，上或下髓质。