Arterial Compression of the Ventro-Lateral Medulla

延髓腹外侧动脉受压

• 批准号: 6464684
• 负责人: SUNIL J PATEL
• 金额: $ 15.14万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-05 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6464684
• 关键词: blood pressure; brain electrical activity; brain mapping; cerebrovascular system; electrostimulus; human subject; medulla oblongata; nerve decompression; neurogenic hypertension; patient oriented research

DESCRIPTION (provided by applicant) The Principal Investigator (PI) is a full time academic neurosurgeon who specializes in surgery of the posterior fossa for neurovascular compression syndromes. This research career award will afford him the time to acquire the skills needed to perform further patient-oriented research in neurogenic hypertension and obtain a Master of Science degree in Clinical Research. The research and training experience he will obtain during the period of the K23 Award will allow him to become an independent clinical investigator with a focus on mechanisms of neurogenic hypertension, and to be able to design and conduct studies on its therapy. The PI has the commitment and support of his sponsor, department and institution to permit the time and allocate the resources needed to attain his research career goals and complete his proposed research. Training will be facilitated through the institutions K30 Award and a NIH supported GCRC. The hypothesis to be tested is that neurogenically mediated hypertension is caused by arterial compression of areas along the retro-olivary sulcus of the ventro-lateral medulla. Therefore the aims of the project are to: 1) electrically establish in humans the locations along the normal surface of the ventro-lateral medulla that are sensitive to stimulation and produce pressor responses; and 2) show an association between arterial compression of these 'pressor-sensitive' areas along the medullary surface (established in Aim 1) and aberrations in sympathetic tone and cardiovascular functions in volunteering subjects with neurogenic hypertension. Hemodynamic and sympathetic response patterns to electrical stimulation of the medullary surface will be recorded to map the location of the pressor-regulating neuronal groups under the surface of the ventro-lateral medulla in patients undergoing surgery of the posterior fossa. This information on response patterns will then be used in a second study to investigate associations between arterial compression of these pressor-regulating areas and similar measured patterns in hypertensive individuals. Results from this research should help to better define the physiologic criteria to be used to relate arterial compression of the ventro-lateral medulla to neurogenic hypertension.

描述(由申请人提供) 首席调查员(PI)是一名全职学术神经外科医生 专门从事神经血管压迫的后颅窝外科手术 综合症。这项研究事业奖将使他有时间获得 进一步开展以病人为中心的神经源性研究所需的技能 高血压，并获得临床研究理学硕士学位。 在此期间，他将获得的研究和培训经验 K23奖将使他成为一名独立的临床研究员，拥有 专注于神经源性高血压的机制，并能够设计和 对其治疗方法进行研究。国际和平协会得到了他的承诺和支持 赞助商、部门和机构允许时间并分配 实现他的研究职业目标和完成他的建议所需的资源 研究。培训将通过机构K30奖和 美国国立卫生研究院支持GCRC。需要检验的假设是，从神经遗传学角度讲 介导性高血压是由动脉压迫沿线区域引起的。 延髓腹外侧的橄榄后沟。 因此，该项目的目标是：1)在人体内建立电学 延髓腹外侧沿正常表面的位置是 对刺激敏感并产生升压反应；以及2)表现出 这些“升压敏感区”的动脉压迫之间的关系 沿着髓表面(在目标1中建立)和像差 自愿者的交感神经张力和心血管功能 神经性高血压。血流动力学和交感神经反应模式 将记录对髓表面的电刺激以标测 升压调节神经元群在颈椎表面下的定位 后颅窝手术患者的延髓腹外侧区。 这些关于反应模式的信息将被用于第二项研究 研究动脉压迫与这些升压调节之间的关系 高血压患者的面积和类似的测量模式。 这项研究的结果应该有助于更好地定义生理学 与腹侧动脉压迫相关的标准 从延髓到神经性高血压。