ELLAGITANNINS & CANCER PREVENTION

鞣花单宁

• 批准号: 6265478
• 负责人: DANIEL W NIXON
• 金额: $ 1.74万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265478
• 关键词: cancer prevention; clinical research; food; fruit; human subject; nutrition related tag; pharmacokinetics; phenols

Ellagic acid, a phenolic compound from the family of Ellagitannins, is naturally found in high concentrations in raspberries, strawberries, and walnuts. For the last 20 years ellagic acid and other ellagitannins have been shown to be effective chemopreventive agents in animal and cell models. The long term goal and objective of this study is to determine if the ellagitannins present in food sources can prevent cancer in humans. Before this can be done, the pharmacokinetic properties of the ellagic acid and the ellagitannins from food sources must be assessd. In the current study volunteers (12) will consume samples of raspberries, strawberries, and walnuts containing similar amounts of ellagitannins. Comparison of the serum and urine levels of ellagitannins will show which food provides the highest concentration of these compounds and is most suited for further study in human chemoprevention clinical trials.

鞣花酸是一种来自鞣花单宁家族的酚类化合物，天然存在于乌藨子、草莓和核桃中。 在过去的20年里，鞣花酸和其他鞣花单宁已被证明是有效的化学预防剂在动物和细胞模型。 本研究的长期目标和目的是确定食物来源中存在的鞣花单宁是否可以预防人类癌症。在此之前，必须评估来自食物来源的鞣花酸和鞣花单宁的药代动力学特性。 在目前的研究中，志愿者（12名）将食用含有相似量鞣花单宁的乌藨子，草莓和核桃样品。 比较血清和尿液中鞣花单宁的水平将显示哪种食物提供这些化合物的最高浓度，并且最适合在人类化学预防临床试验中进行进一步研究。