OBESE HYPERTENSIVE PATIENTS

目的：探讨奥利司他联合低热量饮食对降压药物控制不佳的肥胖型高血压患者52周体重变化的影响(S)。目的：探讨奥利司他加低卡路里饮食对降压药物控制不佳的肥胖型高血压患者52周坐位舒张压控制的影响(S)。次要目标：确定服用奥利司他加低热量饮食与安慰剂加低热量饮食相比，接受奥利司他加低热量饮食治疗的患者达到舒张压9.0毫米汞柱或坐位舒张压较基线下降10毫米汞柱以上的患者的百分比。确定服用奥利司他加低热量饮食的患者与服用安慰剂加低热量饮食的患者相比，体重较基线至少减轻5%的百分比。目的：探讨奥利司他联合低热量饮食对降压药物控制不佳的肥胖型高血压患者坐位收缩压控制的影响(S)。目的：研究奥利司他加低热量饮食对空腹血脂(总胆固醇、高密度脂蛋白、低密度脂蛋白、低密度脂蛋白/高密度脂蛋白比值和甘油三酯)和腰围的影响。以评估奥利司他在这一人群中的安全性。

To determine the effect of orlistat plus a hypocaloric diet on change in body weight over 52 weeks in obese hypertensive patients inadequately controlled with antihypertensive medication(s). To determine the effect of orlistat plus a hypoclaroic diet on sitting diastolic blood pressure control over 52 weeks in obese hypertensive patients inadequately controlled with antihypertensive medication(s).Secondary objectives: To determine the percentage of patients treated with orlistat plus a hypocaloric diet compared to placebo plus hypocaloric diet achieve a diastolic blood pressure <9.0 mmHg or a decrease in sitting diastolic blood pressure of greater than 10 mmHg from baseline. To determine the percentage of patients treated with orlistat plus a hypocaloric diet compared to placebo plus hypocaloric diet achieving at least 5% reduction in body weight from baseline. To determine the effect of orlistat plus a hypocaloric diet on sitting systolic blood pressure control in obese hypertensive patients inadequately controlled with antihypertensive medication(s). To determine the effect of orlistat plus a hypocaloric diet on fasting lipid profile (total cholesterol, HDL, LDL, LDL/HDL ratio and triglycerides) and waist circumference. To assess the safety of orlistat in this population.