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OBESITY, HYPERTENSION, FATTY ACIDS, AND VASCULAR CONTROL

OBESITY, HYPERTENSION, FATTY ACIDS, AND VASCULAR CONTROL
肥胖、高血压、脂肪酸和血管控制
批准号：
6119061
负责人：
BRENT M EGAN
金额：
$1.74万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6119061
关键词：
blood pressure cell proliferation clinical research fatty acids human subject hypertension mitogen activated protein kinase muscle cells obesity vascular endothelium vascular smooth muscle nervous control vasodilation

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英文摘要
The aims of this study: 1)Determine if fat raising NEFA's in lean normotensives reproduce hemodynamic abnormalitites observed in obese hypertensives including elevated BP, enhanced vascular tone and neurovascular reactivity, and impaired endothelium-dependent vasodilation. 2)Determine if lowering NEFAs in obese hypertensives decrease BP, reduce vascular tones and neurovascular reactivity, and enhance endothelium- dependent vasodilation. 3)Determine the signal transduction mechanism(s) by which NEFAs induce mitogenesis and enhance proliferative effects of angiotensin in vascular smooth muscle cells. 4)Identify the PKC-in dependent mechanism(s) by which these same NEFAs impair NOS activity in endothelial cells and endothelium-dependent vasodilation in vascular tissue
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