CHEMICAL COMPOSITION OF DENTAL PLAQUE RELATED TO CARIES

与龋齿有关的牙菌斑的化学成分

• 批准号: 6296279
• 负责人: Racquel Zapanta LeGeros
• 金额: $ 0.17万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6296279
• 关键词: African American; Asian Americans; Hispanic Americans; clinical chemistry; dental caries; dental plaque; epidemiology; human subject; oral health

The purpose of this study is to provide a direct determination of the cariogenic potential of dental plaque from different minority groups through the chemical analysis of whole plaque and its extracellular aqueous phase, referred to as plaque fluid. The cariogenic potential of plaque is primarily influenced by the degree of saturation with respect to tooth mineral and levels of organic acids in plaque fluid, obtained following sucrose exposure. In addition, the mineral ion content of whole plaque appears also to be a caries determinant. These important factors will be assessed in selected groups of Caucasian, Hispanic, Asian, Pacific islanders, and Black subjects who are either caries-free or caries- positive and correlated with other clinical parameters and. in conjunction with the Microbiological Core, with the microbial composition of plaque. These studies will provide a rational basis for differences in caries susceptibility observed in certain minority populations. Total concentrations of inorganic and organic acid ions will be determined in plaque fluid obtained from coronal surfaces of individual members of the various ethnic and racial populations, before and after sucrose exposure. These data will be used to calculate the degree of saturation with respect to tooth mineral. The calcium, phosphate and fluoride contents of whole plaque will also be determined. The combined data will be correlated with the microbiological composition of plaque from the same subject, as described within the Microbiological Core. In addition, findings will also be correlated with other clinical parameters (e.g. fluoride history, dietary habits, salivary flow, plaque index) and the assessment (Spielman/Hay) of adhesion-promoting salivary proteins in the different population samples.

这项研究的目的是提供一个直接的确定 不同少数民族人群牙菌斑致龋潜力的研究 通过对整个斑块及其细胞外的化学分析， 水相，称为菌斑流体。 的致龋潜力 菌斑主要受相对于 牙菌斑液中的牙齿矿物质和有机酸水平， 在蔗糖暴露后。此外，土壤矿物离子含量 牙菌斑似乎也是龋齿的决定因素。这些重要因素 将在选定的白人、西班牙裔、亚裔、太平洋裔 岛民和无龋或有龋的黑人受试者- 与其他临床参数呈正相关。结合 与微生物核心，与菌斑的微生物组成。 这些研究将为龋病的差异提供合理的依据 在某些少数民族中观察到的易感性。 将测定无机和有机酸离子的总浓度 在从个体成员的冠状表面获得的斑块液体中 不同的民族和种族的人口，之前和之后的蔗糖 exposure.这些数据将用于计算饱和度 关于牙齿矿物质。钙、磷酸盐和氟化物 还将测定整个斑块的内容物。合并后的数据将 与来自相同菌斑的微生物组成相关， 如微生物学核心所述。此外，本发明还提供了一种方法， 发现也将与其他临床参数（例如， 氟化物史、饮食习惯、唾液流量、牙菌斑指数）和 评估（Spielman/Hay）促进粘附的唾液蛋白， 不同的人口样本。