CHEMICAL COMPOSITION OF DENTAL PLAQUE RELATED TO CARIES

这项研究的目的是提供一个直接的确定 不同少数民族人群牙菌斑的致龋性研究 通过对整个斑块及其胞外的化学分析 水相，简称斑块流体。中国人的致龋性 斑块主要受以下物质的饱和程度影响 牙齿矿物质和菌斑液中有机酸水平，获得 在接触蔗糖后。此外，整个土壤中的矿物质离子含量 斑块似乎也是龋齿的决定因素。这些重要因素 将在选定的高加索人、西班牙人、亚洲人和太平洋人群体中进行评估 岛民，以及无龋齿或有龋齿的黑人受试者- 与其他临床参数呈正相关，并与其他临床指标呈正相关。结合 具有微生物核心，具有微生物组成的菌斑。 这些研究将为龋病的差异提供合理的依据。 在某些少数群体中观察到易感性。 无机和有机酸离子的总浓度将被测定 在从单个成员的冠状表面获得的斑块液中 蔗糖前后不同民族和种族的人口 曝光。这些数据将被用来计算饱和度 关于牙齿的矿物质。钙、磷和氟化物 还将测定整个斑块的含量。合并的数据将 与同一来源的斑块的微生物组成相关 主题，如微生物学核心中所述。此外, 研究结果还将与其他临床参数相关联(例如 氟化史、饮食习惯、唾液流量、菌斑指数)和 黏附促进唾液蛋白的评估(Spielman/Hay) 不同的总体样本。

The purpose of this study is to provide a direct determination of the cariogenic potential of dental plaque from different minority groups through the chemical analysis of whole plaque and its extracellular aqueous phase, referred to as plaque fluid. The cariogenic potential of plaque is primarily influenced by the degree of saturation with respect to tooth mineral and levels of organic acids in plaque fluid, obtained following sucrose exposure. In addition, the mineral ion content of whole plaque appears also to be a caries determinant. These important factors will be assessed in selected groups of Caucasian, Hispanic, Asian, Pacific islanders, and Black subjects who are either caries-free or caries- positive and correlated with other clinical parameters and. in conjunction with the Microbiological Core, with the microbial composition of plaque. These studies will provide a rational basis for differences in caries susceptibility observed in certain minority populations. Total concentrations of inorganic and organic acid ions will be determined in plaque fluid obtained from coronal surfaces of individual members of the various ethnic and racial populations, before and after sucrose exposure. These data will be used to calculate the degree of saturation with respect to tooth mineral. The calcium, phosphate and fluoride contents of whole plaque will also be determined. The combined data will be correlated with the microbiological composition of plaque from the same subject, as described within the Microbiological Core. In addition, findings will also be correlated with other clinical parameters (e.g. fluoride history, dietary habits, salivary flow, plaque index) and the assessment (Spielman/Hay) of adhesion-promoting salivary proteins in the different population samples.