CHEMICAL COMPOSITION OF DENTAL PLAQUE RELATED TO CARIES

本研究的目的是直接确定 不同少数民族牙菌斑的致龋潜力 通过对整个斑块及其细胞外的化学分析 水相，称为牙菌斑液。 潜在的致龋性 斑块主要受饱和度的影响 获得的牙齿矿物质和牙菌斑液中有机酸的水平 接触蔗糖后。此外，整体矿物质离子含量 牙菌斑似乎也是龋齿的决定因素。这些重要因素 将在选定的白人、西班牙裔、亚洲裔、太平洋裔群体中进行评估 岛民和无龋齿或有龋齿的黑人受试者- 呈阳性且与其他临床参数相关。结合起来 具有微生物核心，具有菌斑的微生物成分。 这些研究将为龋齿的差异提供合理的基础 在某些少数群体中观察到的易感性。 将测定无机酸离子和有机酸离子的总浓度 在从个体成员的冠状表面获得的斑块液中 不同民族和种族人口，食用蔗糖之前和之后 曝光。这些数据将用于计算饱和度 关于牙齿矿物质。钙、磷酸盐和氟化物 整个斑块的含量也将被测定。合并后的数据将 与同一菌斑的微生物组成相关 主题，如微生物学核心中所述。此外， 研究结果还将与其他临床参数相关（例如 氟化史、饮食习惯、唾液流量、菌斑指数）和 评估 (Spielman/Hay) 中促进粘附的唾液蛋白 不同的人群样本。

The purpose of this study is to provide a direct determination of the cariogenic potential of dental plaque from different minority groups through the chemical analysis of whole plaque and its extracellular aqueous phase, referred to as plaque fluid. The cariogenic potential of plaque is primarily influenced by the degree of saturation with respect to tooth mineral and levels of organic acids in plaque fluid, obtained following sucrose exposure. In addition, the mineral ion content of whole plaque appears also to be a caries determinant. These important factors will be assessed in selected groups of Caucasian, Hispanic, Asian, Pacific islanders, and Black subjects who are either caries-free or caries- positive and correlated with other clinical parameters and. in conjunction with the Microbiological Core, with the microbial composition of plaque. These studies will provide a rational basis for differences in caries susceptibility observed in certain minority populations. Total concentrations of inorganic and organic acid ions will be determined in plaque fluid obtained from coronal surfaces of individual members of the various ethnic and racial populations, before and after sucrose exposure. These data will be used to calculate the degree of saturation with respect to tooth mineral. The calcium, phosphate and fluoride contents of whole plaque will also be determined. The combined data will be correlated with the microbiological composition of plaque from the same subject, as described within the Microbiological Core. In addition, findings will also be correlated with other clinical parameters (e.g. fluoride history, dietary habits, salivary flow, plaque index) and the assessment (Spielman/Hay) of adhesion-promoting salivary proteins in the different population samples.