CNS CONSORTIUM--NEW APPROACHES TO BRAIN TUMOR THERAPY

本提案描述了哥伦比亚大学作为参与方的作用 联合体中的机构，其主要长期目标是 提高原发性脑肿瘤患者的生存率。中央 神经系统联盟题为脑肿瘤治疗的新方法 （NABTT），包括七个参与机构：布朗大学， 哥伦比亚大学，克利夫兰诊所，约翰霍普金斯大学， 西北大学马萨诸塞州总医院和 宾夕法尼亚大学. NABTT联盟将开发和执行 有前途的新药的I期和II期临床评价， 生物学方法和给药途径 患有原发性CNS恶性肿瘤的成人。联盟成员还将 协作和共享肿瘤标本、临床数据、实验室数据， 专门知识进行进一步的研究，以大脑的基础生物学 肿瘤和改善个人的护理和生活质量 脑瘤NABTT联盟将依靠约翰的专业知识 霍普金斯大学作为联盟总部，并提供 组织支持、生物统计和数据分析、质量控制 和研究监测。哥伦比亚大学在世界大学体系中的作用 联合体将在20个或25个国家执行联合体批准的方案， 每年有更多的脑肿瘤患者，参加组织 为联盟进行规划，并在其他相关的大脑方面进行合作 肿瘤研究项目。该提案描述了哥伦比亚的资源， 神经肿瘤学的能力，这将有助于其参与 这份有价值的合作协议

This proposal describes the role of Columbia University as a Participating Institution in a consortium whose primary long-term objective is to improve the survival of patients with primary brain tumors. The Central Nervous System Consortium is titled New Approaches to Brain Tumor Therapy (NABTT) and includes seven participating institutions: Brown University, Columbia University, The Cleveland Clinic, The Johns Hopkins University, The Massachusetts General Hospital, Northwestern University and the University of Pennsylvania. The NABTT Consortium will develop and perform Phase I and Phase II clinical evaluations of promising new agents, novel biological approaches and routes of administration in the treatment of adults with primary CNS malignancies. The Consortium members will also collaborate and share tumor specimens, clinical data, laboratory data and expertise to conduct additional research into the basic biology of brain tumors and improving the care and quality of life of individuals with brain tumors. The NABTT Consortium will rely on the expertise of the Johns Hopkins University to serve as the Consortium Headquarters and to provide organizational support, biostatistical and data analysis, quality control and study monitoring. The function of Columbia University within the Consortium will be to conduct consortium-approved protocols on twenty or more brain tumor patients per year, to participate in organizational planning for the consortium and to collaborate on other related brain tumor research projects. This proposal describes Columbia's resources and capabilities in neur-oncology which will facilitate its participation in this worthwhile cooperative agreement.