ACQUISITION OF 500 MHZ NMR SPECTROMETER

该提案要求为垂直钻孔提供部分资金， 用于高分辨率光谱研究的野外核磁共振波谱仪 结构生物学该仪器将由11.75特斯拉 磁体，足够均匀的体积，可容纳高达8 mm的样品管， 和光谱仪硬件，具备高级 梯度增强光谱、三重共振 实验、过采样能力、数字滤波等 现代多维NMR方法所需的其他功能。 光谱仪将由五个主要用户组成的核心小组使用 (all与校外资助核磁共振研究）和几个小 用户.主要用户的项目侧重于NMR应用， 结构生物学计划使用拟议的光谱仪进行研究 强调生物分子结构的研究。调查人员已 建立了核磁共振研究的计划， 能力，而建议书记录了 通过拟议仪器的新功能获得。 拟议的文书将在加州大学戴维斯分校的主持下 NMR设备。该设施有超过17年的证明记录， 实施最先进的NMR技术，并在光谱仪 维护和修改。

This Proposal requests partial funding for a vertical bore, high field NMR spectrometer for high resolution spectroscopic studies in structural biology. The instrument will consist of a 11.75 Tesla magnet, sufficient homogeneous volume for up to 8 mm sample tubes, and spectrometer hardware with all features necessary for advanced techniques such as gradient enhanced spectroscopy, triple resonance experiments, oversampling capability, digital filtering, and all other features necessary for modern multidimensional NMR methods. The spectrometer will be utilized by a core group of five Major Users (all with extramural funding for NMR research) and several minor users. The projects of the Major Users focus on NMR applications to structural biology. Planned research using the proposed spectrometer emphasizes studies of biomolecule structure. The investigators have established programs of NMR research with spectrometers of lesser capability, and the Proposal documents the additional knowledge to be gained by the new capabilities of the proposed instrument. The proposed instrument will come under the auspices of the UC Davis NMR Facility. The Facility has a proven record of over 17 years in implementing state-of-the-art NMR techniques, and in spectrometer maintenance and modification.