ACQUISITION OF 500 MHZ NMR SPECTROMETER

购买 500 MHZ 核磁共振波谱仪

• 批准号: 2040625
• 负责人: GERD N LA MAR
• 金额: $ 40万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2040625
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

This Proposal requests partial funding for a vertical bore, high field NMR spectrometer for high resolution spectroscopic studies in structural biology. The instrument will consist of a 11.75 Tesla magnet, sufficient homogeneous volume for up to 8 mm sample tubes, and spectrometer hardware with all features necessary for advanced techniques such as gradient enhanced spectroscopy, triple resonance experiments, oversampling capability, digital filtering, and all other features necessary for modern multidimensional NMR methods. The spectrometer will be utilized by a core group of five Major Users (all with extramural funding for NMR research) and several minor users. The projects of the Major Users focus on NMR applications to structural biology. Planned research using the proposed spectrometer emphasizes studies of biomolecule structure. The investigators have established programs of NMR research with spectrometers of lesser capability, and the Proposal documents the additional knowledge to be gained by the new capabilities of the proposed instrument. The proposed instrument will come under the auspices of the UC Davis NMR Facility. The Facility has a proven record of over 17 years in implementing state-of-the-art NMR techniques, and in spectrometer maintenance and modification.

该提案要求为垂直钻孔提供部分资金， 用于高分辨率光谱研究的野外核磁共振波谱仪 结构生物学该仪器将由11.75特斯拉 磁体，足够均匀的体积，可容纳高达8 mm的样品管， 和光谱仪硬件，具备高级 梯度增强光谱、三重共振 实验、过采样能力、数字滤波等 现代多维NMR方法所需的其他功能。 光谱仪将由五个主要用户组成的核心小组使用 (all与校外资助核磁共振研究）和几个小 用户.主要用户的项目侧重于NMR应用， 结构生物学计划使用拟议的光谱仪进行研究 强调生物分子结构的研究。调查人员已 建立了核磁共振研究的计划， 能力，而建议书记录了 通过拟议仪器的新功能获得。 拟议的文书将在加州大学戴维斯分校的主持下 NMR设备。该设施有超过17年的证明记录， 实施最先进的NMR技术，并在光谱仪 维护和修改。

项目成果

Efficient method for the preparation of peracetylated Neu5Ac2en by flash vacuum pyrolysis.

闪蒸真空热解制备全乙酰化 Neu5Ac2en 的有效方法。

• DOI: 10.1021/jo900224t
• 发表时间: 2009
• 期刊: The Journal of organic chemistry
• 作者: Horn,EvanJ;Gervay-Hague,Jacquelyn
• 通讯作者: Gervay-Hague,Jacquelyn

Preparation of a conjugation-ready thiol responsive molecular switch.

准备缀合的硫醇响应分子开关。

• DOI: 10.1016/j.tetlet.2015.10.019
• 发表时间: 2015
• 期刊: Tetrahedron letters
• 影响因子: 1.8
• 作者: Tautges,Brandon;Or,Victor;Garcia,Joel;Shaw,JaredT;Louie,AngeliqueY
• 通讯作者: Louie,AngeliqueY

Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors.

基于砜的核苷酸电子等排体的合成：CMP-唾液酸合成酶抑制剂的鉴定。

• DOI: 10.1039/b819155g
• 发表时间: 2009
• 期刊: Organic & biomolecular chemistry
• 影响因子: 3.2
• 作者: Wong,JessicaH;Sahni,Urvashi;Li,Yanhong;Chen,Xi;Gervay-Hague,Jacquelyn
• 通讯作者: Gervay-Hague,Jacquelyn

Sagittamides A and B. Polyacetoxy long-chain acyl amino acids from a didemnid ascidian.

Sagittamides A 和 B。来自二月海鞘的聚乙酰氧基长链酰基氨基酸。

• DOI: 10.1021/ol050717x
• 发表时间: 2005
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Lievens,SarahC;Molinski,TadeuszF
• 通讯作者: Molinski,TadeuszF

Selective acetylation of per-O-TMS-protected monosaccharides.

• DOI: 10.1021/ol101751d
• 发表时间: 2010-10-01
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Witschi, Mark A.;Gervay-Hague, Jacquelyn
• 通讯作者: Gervay-Hague, Jacquelyn