FUNCTIONAL ORGANIZATION OF THE BRAIN IN CHILDREN WITH ADHD--INTERVENTION EFFECTS

项目一将研究注意力的神经生物学基础- 缺陷/多动症（ADHD），使用功能性磁共振 功能磁共振成像（fMRI）来研究在最初的中心计划招募的儿童。 具体而言，最初评估为7.5-13.3岁的儿童将被 在11-16岁时进行系统性重新评估。样品和 我们研究小组在使用功能磁共振成像方面取得的重大进展使我们能够 实现四个具体目标： 1.为了确定大脑的功能组织（使用功能磁共振成像）， ADHD和ADHD的亚组（ADHD/IT，ADHD/CT），以确定是否 特定的大脑激活模式为特定的 在项目初期确定的分组。 2.确定与RD共病对脑激活的影响 （2）ADHD与RD的关系（ADHD without RD and ADHD with RD） 3.确定药物治疗对大脑激活的影响 模式：a）ADHD亚组内和B）儿童组间 ADHD和RD共病，即，ADHD不伴RD和ADHD伴RD。 4.将fMRI确定的大脑激活模式与 在认知（特别是注意力和语言）过程中 比较：a）ADHD与正常人; B）ADHD亚组（ADHD 注意力不集中vs ADHD组合型）; c）ADHD伴和不伴RD; d） 药物治疗的效果。

Project I will examine the neurobiological underpinnings of Attention- Deficit/Hyperactivity Disorder (ADHD), using functional magnetic resonance imaging (fMRI) to study children recruited in the initial Center program. Specifically, children initially assessed at 7.5-13.3 years will be systematically re-evaluated at ages 11-16 years. The sample and the significant progress made by our research group in using fMRI allow us to address four specific aims: 1. To determine the functional organization of the brain (using fMRI) in ADHD and within subgroups of ADHD (ADHD/IT, ADHD/CT), to determine whether particular brain activation patterns provide a "signature" for specific subgroups identified during the initial project period. 2. To determine the influence of comorbidity with RD on brain activation patterns (comparing ADHD without RD and ADHD with RD). 3. To determine the effects of pharmacotherapy on brain activation patterns: a) within subgroups of ADHD and b) between groups of children comorbid for ADHD and RD, i.e., ADHD without RD and ADHD with RD. 4. To relate brain activation patterns as determined with fMRI to changes in cognitive (particularly attentional and linguistic) processes comparing: a) ADHD with normals; b) within subgroups of ADHD (ADHD Inattentive vs ADHD combined type); c) ADHD with and without RD; d) effects of pharmacotherapy.