MASS SPECTROMETRY

这份修订后的申请描述了一种高效且经济的计划 我们新重组的质谱学设施为五个人服务 BRTP的使命。一名中央工作人员将为 仪器的操作和维护、培训、口译 数据，以及对参与技术的研究助理的监督 研究及发展(TRD)项目，涉及发展 MALDL离子结构分析的化学和仪器方法 在生物聚合物的分析中。研究助理也将为 作为我们的用户社区和独立用户之间的互动联络- 资助该基金的合作调查员和私人投资机构的研究项目。 此建议与多个独立关联的主动交互 资助的项目将丰富用户可用的技术基础，并 帮助确保TRD的工作针对用户的需求 设施的一部分。与大分子结构(肽)的相互作用 位于质谱学设施旁边的设施将 继续加强每个设施的专业知识和能力 为用户服务。 质谱学设施拥有9个质谱仪，其中5个 主要致力于80多个国家的利益 地方、地区和国家科学领域的生物医学研究人员 社区。质谱学设施是一所共享的大学 MSU协助采购主要设备的设施 鼓励创新研究活动，并提供最先进的 校园内最先进的仪器设备和研究基地。培训仍在继续 作为质谱学设施的一项主要活动 大约20名博士生正在进行研究， 私家侦探和协查人员的方向。然而，没有财务上的 在这份申请中，我们需要研究生的支持。支持 需要三名研究助理，他们将获得高级 在质谱学方面的培训，以及世卫组织，以及PI和合作- 调查人员将在质谱学设施中进行TRD。 正规的质谱学培训可通过学术途径获得 密歇根州立大学的课程，以及通过一个以短片形式的外展项目 由美国化学学会赞助的课程，作为校外课程 仅供授课的版本和为期五天的校园“动手”计划。

This revised application describes an efficient and economical plan for our newly reorganized Mass Spectrometry Facility to serve the five missions of BRTP. A central staff will provide technical support for operation and maintenance of instruments, training, interpretation of data, and supervision of research associates involved in Technological Research and Development (TRD) projects involving the development of chemical and instrumental approaches to structure analysis of MALDL ions in the analysis of biopolymers. The research associates also will serve as interactive liaisons between our user community and independently- funded research projects of the Facility's co-investigators and PIs. This proposed active interaction with several associated independently funded projects will enrich the technology base available to users and help ensure that efforts in TRD are directed toward the needed of users of the Facility. Interaction with the Macromolecular Structure (Peptide) Facility, located adjacent to the Mass Spectrometry Facility, will continue to enhance the expertise and capabilities of each facility in serving its users. The Mass Spectrometry Facility houses nine mass spectrometers, five of which are dedicated principally to the interests of more than 80 biomedical investigators in the local, regional, and national scientific community. The Mass Spectrometry Facility is a shared University Facility in that MSU has assisted in the acquisition of major equipment to stimulate innovative research activities and to provide a state-of- the-art instrumentation and research base on campus. Training continues to be a major activity of the Mass Spectrometry Facility where approximately 20 Ph.D. graduate students are conducting research under the direction of the PIs and co-investigators. However, no financial support is requested in this application for graduate students. Support is requested for three research associates who will obtain advanced training in mass spectrometry and who, along with the PIs and co- investigators, will conduct TRD in the Mass Spectrometry Facility. Formal training in mass spectrometry is available through academic programs at MSU as well as via an outreach program in the form of a Short Course sponsored by the American Chemical Society both as an off-campus lecture-only version and as a five-day on-campus "hands-on" program.