NEUROLOGIC ASPECTS OF LYME DISEASE IN NORTH AMERICA

莱姆病在美国是一种主要的新兴感染， 在公众意识、健康、 医疗成本和医疗实践标准。神经系统受累现在 被认为是莱姆病的主要发病率，但还没有 以系统的方式研究。该项目已汇集了一个 研究神经莱姆病的跨学科研究小组。 他们将利用莱姆的临床和实验室资源 斯托尼布鲁克的疾病中心。本计划项目的所有组成部分 通过共享的方法、概念框架和共同核心联系起来。 这三个临床项目将为发病机制提供材料 项目名称： 项目1将研究宿主因素（T细胞反应）的作用， 生物体因素（嗜神经性、抗原变异）。 项目2将确定中心的频率，相关因素和结果 莱姆病早期神经系统侵犯 项目3将描述慢性莱姆病的神经行为综合征 疾病 项目4将研究儿童神经系统莱姆病。 支持核心是：A）管理中心核心; B）数据 管理核心; C）中心实验室核心; D）神经心理学核心。 本项目的主要科学目标是：（1）确定 并前瞻性地描述神经学、神经心理学和 儿童和成人莱姆病的社会心理表现;以及2） 以确定神经系统莱姆病的发病机制。 次要目标是3）表征相关的脑脊液 改变;和4）识别不良结局的风险因素。 该计划项目将支持结构化的跨学科努力， 研究莱姆病的神经方面它将提供信息 引导发展 合理和具有成本效益的公共卫生政策， 感染

Lyme disease is a major emerging infection in the United States, and has become a significant health issue in terms of public awareness, health care costs, and medical practice standards. Neurologic involvement is now recognized as the major morbidity of Lyme disease, but has not been studied in a systematic fashion. This Program Project has assembled an interdisciplinary team of investigators to study neurologic Lyme disease. They will utilize the clinical and laboratory resources of the Lyme Disease Center at Stony Brook. All components of this Program Project are linked by shared methodologies, conceptual frameworks, and common Cores. The three Clinical Projects will provide materials for the Pathogenesis Project: Project 1 will look at the role of host factors (the T cell response) and organism factors (neurotropism, antigenic variation). Project 2 will determine the frequency, correlates, and outcome of central nervous system invasion in early Lyme disease. Project 3 will characterize the neurobehavioral syndromes of chronic Lyme disease. Project 4 will study neurologic Lyme disease in children. The supporting Cores are: A) an Administrative Center Core; B) a Data Management Core; C) a Central Laboratory Core; D) a Neuropsychology Core. The primary scientific goals of this Program Project are 1) to identify and characterize prospectively the neurologic, neuropsychologic, and psychosocial manifestations of Lyme disease in children and adults; and 2) to identify pathogenetic mechanisms involved in neurologic Lyme disease. The secondary goals are 3) to characterize associated cerebrospinal fluid changes; and 4) to identify risk factors for poor outcome. This Program Project will support a structured interdisciplinary effort to study the neurologic aspects of Lyme disease. It will provide information to guide development of rational and cost-effective public health policy for this important infection.