Involvement of brain-derived neurotrophic factor gene polymorphism on the central nervous system disorders of alcoholics

脑源性神经营养因子基因多态性与酗酒者中枢神经系统疾病的关系

• 批准号: 22591260
• 负责人: WAKUDA Tomoyasu
• 金额: $ 2.83万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591260/
• 关键词: 中毒性精神障害; アルコール依存; MRI; 神経画像; アルコール依存症; 認知機能; BDNF

Cognitive dysfunction and brain atrophy observed in alcoholics could improve partially by abstinence. Brain-derived neurotrophic factor (BDNF), a factor adjusting the neuronal growth, synaptic functions, and survival and growth of neurons in the brain, shows neuroprotective effects. Polymorphism of the BDNF gene has been associated with risk of neuropsychiatric disorders such as schizophrenia and mood disorders, although relationship between BDNF gene polymorphism and recovery from alcohol intoxication is unclear. In this study, we examined this issue. As a result, we found no significant effect of BDNF gene polymorphism in the control as well as patients groups in any of neuroimaging findings, suggesting that further evaluations with more participants will be required.

戒酒可以部分改善酗酒者的认知功能障碍和脑萎缩。脑源性神经营养因子（BDNF）是一种调节脑内神经元生长、突触功能以及神经元存活和生长的因子，具有神经保护作用。BDNF基因的多态性与神经精神疾病如精神分裂症和情绪障碍的风险有关，尽管BDNF基因多态性与酒精中毒恢复之间的关系尚不清楚。在这项研究中，我们研究了这个问题。结果，我们发现对照组和患者组中BDNF基因多态性对任何神经影像学结果均无显著影响，这表明需要更多参与者进行进一步评估。

项目成果

Alteration of plasma glutamate and glutamine levels in children with high-functioning autism.

• DOI: 10.1371/journal.pone.0025340
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Shimmura C;Suda S;Tsuchiya KJ;Hashimoto K;Ohno K;Matsuzaki H;Iwata K;Matsumoto K;Wakuda T;Kameno Y;Suzuki K;Tsujii M;Nakamura K;Takei N;Mori N
• 通讯作者: Mori N

Vldlr overexpression causes hyperactivity in rats.

• DOI: 10.1186/2040-2392-3-11
• 发表时间: 2012-10-30
• 期刊: Molecular autism
• 影响因子: 6.2
• 作者: Iwata K;Izumo N;Matsuzaki H;Manabe T;Ishibashi Y;Ichitani Y;Yamada K;Thanseem I;Anitha A;Vasu MM;Shimmura C;Wakuda T;Kameno Y;Takahashi T;Iwata Y;Suzuki K;Nakamura K;Mori N
• 通讯作者: Mori N

Failure to Confirm Genetic Association of the FXYD6 Gene With Schizophrenia: The Japanese Population and Meta-Analysis

• DOI: 10.1002/ajmg.b.31095
• 发表时间: 2010-09-01
• 期刊: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
• 影响因子: 2.8
• 作者: Iwata, Yasuhide;Yamada, Kazuo;Yoshikawa, Takeo
• 通讯作者: Yoshikawa, Takeo

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease

• DOI: 10.1007/s00259-010-1612-0
• 发表时间: 2011-02-01
• 期刊: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• 影响因子: 9.1
• 作者: Yokokura, Masamichi;Mori, Norio;Ouchi, Yasuomi
• 通讯作者: Ouchi, Yasuomi